PDE Screening & Profiling Services

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Overview

Phosphodiesterase (PDE) targets remain among the most biologically validated yet development-challenging enzyme families in modern drug discovery. The complexity introduced by multiple families, isoforms, splice variants, and tissue-specific regulation has repeatedly proven that early, high-resolution screening and selectivity profiling are not optional—but decisive.

Creative Biogene provides a comprehensive, execution-ready PDE screening and profiling platform designed to help drug discovery teams rapidly identify viable leads, de-risk selectivity liabilities, and generate decision-grade data aligned with downstream pharmacology and development strategies.

Figure 1. Domains of the eleven PDE families and Crystal Structure of the Full-Length PDE2A Dimer. (DeNinno MP. et al., 2012)

Built for the Real Challenges of PDE Drug Discovery

Despite decades of research and several landmark approvals, productivity in PDE drug development has historically been limited by:

High homology across catalytic domains
Poor isoform and splice-variant selectivity
Late-emerging off-target liabilities
Inadequate translational relevance of early screening data

Creative Biogene's PDE screening strategy is engineered specifically to address these challenges—from biochemical mechanism to cellular context—enabling confident progression beyond early discovery.

A Versatile Assay Platform from Enzyme to Cell

Creative Biogene's kinase platforms are engineered to meet these challenges, combining biochemical precision with cellular relevance to generate data that directly informs medicinal chemistry and downstream development. Based on an extensive portfolio of validated kinase assays, Creative Biogene supports kinase programs at every discovery stage:

A Mature PDE Assay Portfolio Covering the Full Superfamily

We offer one of the most extensive commercial PDE assay panels, supporting both focused programs and broad selectivity assessment:

Full-length human enzymes, catalytic domains, and selected species variants
Support for dual-substrate (cAMP/cGMP) and substrate-specific PDEs
Flexible panel configuration for hit-to-lead and lead optimization stages

Integrated Screening from Enzyme Inhibition to Cellular Function

Creative Biogene delivers end-to-end PDE screening and profiling services, including:

Primary enzymatic inhibition screening
IC₅₀ determination and potency ranking
Cross-family and intra-family selectivity profiling
Radiolabeled biochemical assays for high-confidence kinetic data
Cell-based functional assays reflecting intracellular signaling context

Why Choose Creative Biogene?

Data Quality First

Radiolabel-based assays and rigorously validated protocols deliver reproducible, decision-grade datasets.

Breadth Without Compromise

Choose from 20+ PDE targets with consistent assay performance across families and isoforms.

Expert-Driven Execution

Our scientists bring 10+ years of hands-on experience in PDE-focused drug discovery, providing not just data, but actionable interpretation and project guidance.

Speed with Scientific Rigor

Optimized workflows enable fast turnaround times without sacrificing assay robustness or biological relevance.

Beyond Screening: Enabling PDE Target Biology

To support deeper mechanistic and translational studies, Creative Biogene also provides a full suite of PDE gene-related research tools, including:

Stable PDE-expressing cell lines
Premade viral particles
Recombinant proteins and cell lysates
Cloning services and RNAi reagents

These resources allow seamless expansion from compound screening into target validation, pathway interrogation, and biomarker development.

Key PDE Targets Available

Custom targets, splice variants, and tailored assay configurations are available upon request.

PDE1A	PDE1C	PDE3B	PDE4B	PDE4D	PDE6
PDE1B	PDE2A	PDE3A	PDE4A	PDE4C	PDE5

A Strategic Partner for PDE-Focused Programs

The future of PDE drug discovery lies beyond simple catalytic inhibition—toward isoform-aware, context-specific modulation strategies. Creative Biogene's screening platforms are designed to support this evolution, helping you generate the data needed to make confident, forward-looking decisions. Tell us your scientific question. We will design the screening strategy to answer it. Contact Creative Biogene today to discuss customized PDE screening and profiling solutions for your program.

* For research use only. Not intended for any clinical use.

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