Creative Biogene is providing a large-scale selection of PDE assays to meet the growing need for robust PDE screening and profiling. Analyzing your compounds with our PDE panel can help minimize risks and increase successes. In the same time, our biochemical and cell-based PDE screening and profiling services will also accelerate your drug discovery program.
With years of experience in PDE assay services, Creative Biogene is able to provide comprehensive services including inhibitory effects, selectivity and IC50 determination of compounds on the PDE superfamily. Creative Biogene offers biochemical and cell-based PDE screening and profiling assays in PDE-based drug discovery. It is our commitment to provide you effective solution and high-quality data with fast turnaround time.
Phosphodiesterases (PDEs) are a superfamily of enzymes that degrade cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP). There are now 11 PDE families identified, many of which exist as splice variants. PDEs influence a number of pharmacological processes, including proinflammatory mediator production and action, ion channel function, muscle contraction, learning, differentiation, apoptosis, lipogenesis, glycogenolysis, and gluconeogenesis.
As indispensable regulators of cyclic nucleotide signaling with diverse physiological functions, PDEs have been recognized as important drug targets for treating various diseases, such as CNS, oncology, heart failure, depression, asthma, inflammation and erectile dysfunction (Jeon et al. 2005). Meanwhile, PDEs have been exploited pharmacologically for more than half a century, and some of the most successful worldwide drugs also affect the function of PDEs.
Fig.1 Overview of the PDE complex structures
Creative Biogene has the largest range of commercial PDE assays including an extensive panel of full-length human isoforms, catalytic domains and species variants. Our recombinant PDE enzymes are expressed in special cells to ensure high expression and precise post-translational modification making them perfect for functional and cell-free PDE assays.
Advantages of PDE screening and profiling services in Creative Biogene:
- Radiolabel assays for high-quality enzymatic assays
- Choose from over 20 PDEs, covering from PDE1 to PDE11
- Get questions answered or project guidance in a high efficient way
With over 10 years’ experience in phosphodiesterase drug discovery, Creative Biogene has developed different platforms which can meet the needs of different researchers. Our experienced experts are dedicated to identifying the compounds with the greatest chance to succeed in PDE screening and profiling. Creative Biogene is a reliable partner who can help you accelerate the speed to achieve your research goals.
If you have any special requirements in PDE compound screening, please feel free to contact us at firstname.lastname@example.org or 1-631-626-9181. We are looking forward to working together with your attractive projects.
- Y. H. Jeon, Y. -S. Heo, C. M. Kim, Y. -L. Hyun, T. G. Lee, S. Ro and J. M. Cho. (2005) ‘Phosphodiesterase: overview of protein structures, potential therapeutic applications and recent progress in drug development Cell’, Mol. Life Sci., 62, 1198–1220.