Gene Editing Animal Model Generation Service

Animal models that reproduce human diseases are important for various disease research as well as drug development. Genome editing tools based on the CRISPR-Cas9 system are a breakthrough technology that allows the precise introduction of mutations at the target DNA sequences. The development of CRISPR-Cas9 technology has accelerated the creation of animal models and greatly facilitated related research. The development of the clustered regularly interspaced short palindromic repeats (CRISPR) system has enabled a faster and cheaper production of animal models compared with traditional methods.

Creative Biogene utilizes the CRISPR-Cas9 system to provide gene editing and model development services for a variety of model animals, including mice, rats, zebrafish, C.elegans, and many other species. Our experienced gene editing team, combined with our advanced technology platform, is dedicated to creating stable gene modification programs in animals, including knockouts, point mutations, short insertions, knock-ins and conditional knock-ins. We use a variety of technologies and strategies to provide customized solutions to our clients' demands in order to accelerate their relevant basic research and drug development processes.

Gene Editing Animal Model Generation Service at Creative Biogene

Creative Biogene offers a comprehensive range of services, including model animal selection and customization of gene modification strategies. With the power of CRISPR, we are able to efficiently and accurately modify animal genomes, enabling researchers to gain insights into gene function, disease mechanisms and potential therapeutic interventions.

Model selection

Creative Biogene's platform offers a wide selection of models, including mouse, rat, zebrafish, C.elegans, etc., which are suitable for different aspects of genetic research. Our experienced researchers work closely with clients to understand their research demands and combine the features and advantages of different models to select the most suitable animal model for the next step of genetic modification.

Animal Models	Features
Mouse	The most widely used animal model in biomedical research. Well-annotated genomes, rapid reproductive cycles, and genetic similarities to humans. Extremely valuable in a wide range of studies including cancer research, neuroscience and immunology.
Rat	Physiologically and anatomically similar to humans. Commonly used in preclinical studies for drug discovery, toxicology and disease modeling.
Zebrafish	High similarity to human genes, transparent embryos, easy to observe. Commonly used in developmental biology, gene function research, disease pathogenesis research and high-throughput drug screening.
C.elegans	A common model for the study of fungal infections and pathogenesis.

Gene editing strategies

Creative Biogene's integrated platform covers a comprehensive range of gene editing strategies. We provide custom-modeled gene editing strategies based on our clients' research demands. Our scientists have specialized knowledge and extensive experience in the following areas:

Gene editing strategies	Description	Applications
Knockout	Creating animals with specific genes completely disabled or deleted.	Gene function, physiological function and disease mechanism research.
Conditional knockout	Creation of conditional knockout models by the Cre-LoxP recombinase system.	Genes expression, regulation and function research.
Knock-in	Insertion of specific gene sequences into an animal's genome.	Gene function, mutant gene effects and disease modeling research.
Conditional knock-in	Gene inserts were created in animals by the Cre-Lox system.	Gene function research.
Point mutation	Introducing single nucleotide changes for specific genes.	Gene function, physiological function and disease mechanism research.
Short insertion	Insertion of small DNA fragments into specific genes.	Gene function, physiological function and disease mechanism research.

Genome Editing Animal Model Generation Workflow

What We Deliver?

Gene editing animal models
Model validation

Creative Biogene's experts are ready to help. Our team will work with you to develop the best strategy for generating gene-edited animal models to support your research program. Contact us to learn more about our services.

* For research use only. Not intended for any clinical use.

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