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COVID-19 Solutions

Coronavirus disease 2019 (COVID-2019) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged in Wuhan, China in December 2019. The ongoing pandemic has swept globally and infected millions of people due to its high transmissibility and pathogenicity, posing an unprecedented threat to people’s health. As a global leading company, Creative Biogene provides comprehensive products and services to help fight against this outbreak.

COVID-19 Solutions

SARS-CoV-2 is an enveloped, non-segmented, positive sense RNA virus, belonging to Betacoronavirus. Cellular entry of coronaviruses depends on the binding of the spike (S) protein to a specific cellular receptor and subsequent S protein priming by cellular proteases. Studies have shown that ACE2 is the receptor of SARS-CoV-2 and serine protease TMPRSS2 is for S protein priming. Based on these findings, scientists are focusing on the study of the two targets for drug development and trying to develop drugs by interrupting the process.

With researchers and scientists around the world working closely together, Creative Biogene also makes its own contribution to this battle against COVID-19. We are now dedicated to providing supportive services and products to both academics and industries with our long-term commitments for global clients. We will work closely with you to accelerate the progress of further research, drug discovery and vaccine development. Our services and products cover from plasmids, aptamers, cell lines, pseudoviruses to animal models. In addition, we provide customized services and products based on your demands. The major aspects of our services are shown down below:

COVID-19 Solutions

Featured COVID-19 Research Solutions Provided by Creative Biogene:

  • Gene Synthesis and Cloning

SARS-CoV-2 related plasmids are now available for global customers. We also provide plasmids encoding human genes such as ACE2 and TMPRSS2. In addition, we provide customized plasmid construction service according to the specific needs.

SARS-CoV-2 ORF Clones     Related Clones and Plasmids

ACE2 and TMPRSS2 involve in the entry of SARS-CoV-2. Based on highly optimized and efficient strategies, we have generated different kinds of cell lines, including but not limited to ACE2/TMPRSS2 overexpression cell lines and KO cell lines.

We provide pseudoviruses service based on lentiviral and VSV systems for SARS-CoV-2 studies due to its safety. This system has been applied as a reference for the virus detection. In addition, it also plays a role in virus receptor research and vaccine development.

  • Diagnostic Assays

Diagnostic assays are important for identification of SARS-CoV-2. We provide comprehensive services from custom assay design, development and manufacturing. Multiple assays such as qPCR, colloidal gold, ELISA, FISH are available for global customers.

SARS Cov2 Test Kits

In addition, we also offer animal model construction and related testing services for drug discovery and vaccine development.

  • Others

Creative Biogene also provides SARS-CoV-2 related products including aptamers, dNTPs, recombinant proteins, antibodies to promote the success of this combat.

SARS-Cov2 Recombinant Proteins     SARS-Cov2 Antibodies

Why Choose Creative Biogene

  • All our projects are run by PhD scientists
  • Comprehensive services and products are available
  • Leading-edge equipment and best-in-class technologies
  • Fast delivery time with high quality
  • Competitive price
  • Customize services and products

Creative Biogene is your reliable partner and we will fight against COVID-19 together. If you are interested in our services, please feel free to contact us.

References:

  1. Hoffmann, M., Kleine-Weber, H., Schroeder, S., Krüger, N., Herrler, T., Erichsen, S., Schiergens, T.S., Herrler, G., Wu, N.H., Nitsche, A., Müller, M.A., Drosten, C., Pöhlmann, S..(2020)SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor. Cell, 181(2):271-280.
  2. Lan. J., Ge, J., Yu, J., Shan, S., Zhou, H., Fan, S., Zhang, Q., Shi, X., Wang, Q., Zhang, L., Wang, X..(2020) Structure of the SARS-CoV-2 spike receptor-binding domain bound to the ACE2 receptor. Nature.

Related Products and Services at Creative Biogene

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* For research use only. Not intended for any clinical use.
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