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Adenoviruses have a very broad host range, and can infect human and other mammalian cell lines or primary cells, including replicative as well as non-replicative cells. There is no integration with the host system. A high gene expression level can be reached in very short time.
Adeno-associated virus (AAV) is a small replication-defective, nonenveloped virus which can infect both dividing and non-dividing cells. AAV is not currently known to cause disease and consequently the virus causes a very mild immune response. It is a very attractive candidate for gene delivery study.
Lentivirus is a powerful tool for delivering target genes into almost all types of dividing and non-dividing mammalian cells and may incorporate its genome into that of the host cells. A stable and long-term gene expression can be obtained due to its high transduction efficiency and broad host range.
Creative Biogene's Premade Virus Particles provide the following advantages: