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RNA interference (RNAi) is a biological process in which RNA molecules inhibit gene expression or translation, by neutralizing targeted mRNA molecules. RNAi can be used for identification and validation of drug targets as well as in the discovery of cell-signaling pathways that are vital to organism survival and disease control. This technology is crucial to the development of new therapeutic drugs and treatments.
Figure 1. RNAi mechanism. 
The applications of RNAi can be mediated through two types of molecules; the chemically synthesized double-stranded small interfering RNA (siRNA) or vector based short hairpin RNA (shRNA). shRNA is an artificial RNA molecule with a tight hairpin turn that can be used to silence target gene expression via RNA interference (RNAi). Expression of shRNA in cells is typically accomplished by delivery of plasmids or through viral or bacterial vectors. shRNA is an advantageous mediator of RNAi in that it has a relatively low rate of degradation and turnover. While, siRNA is a class of double-stranded RNA molecules, 20-25 base pairs in length, similar to miRNA, and operating within the RNA interference (RNAi) pathway. It interferes with the expression of specific genes with complementary nucleotide sequences by degrading mRNA after transcription, preventing translation. Both shRNA and siRNA can be used for protein knockdown.
As one of the leading biotechnology company in the world, Creative Biogene has the extensive experience and expertise to provide you high-quality RNAi products, including siRNA libraries and shRNA clones. Creative Biogene’s goal is to provide you with effective, reliable and convenient tool to accelerate your RNAi research.