Our promise to you:
Guaranteed product quality, expert customer support.
24x7 CUSTOMER SERVICE
CONTACT US TO ORDER
Gene therapy has revolutionized modern medicine by providing innovative treatments for inherited diseases, cancers, and rare diseases. Adeno-associated virus (AAV), one of the most widely used viral vectors for gene therapy, has garnered significant attention due to its excellent safety profile, high transduction efficiency, and ability to deliver therapeutic genes to both dividing and non-dividing cells. This unique combination has propelled AAV-based therapies toward the clinic, with several landmark approvals and hundreds more in active development worldwide. However, the successful use of AAV vectors in research and the clinic depends on the accurate determination of their titer, i.e., the concentration of viral particles in a specific sample.
Accurate titer determination is critical at multiple stages of AAV production and application:
(1) Upstream production optimization: During AAV vector production, monitoring viral titer ensures efficient production and helps identify potential process improvements.
(2) Downstream purification: Assessing titer before and after purification steps ensures high yield and purity of the final product.
(3) Dose determination in preclinical and clinical studies: In gene therapy trials, accurate titer determination is crucial for achieving consistent and effective dose determination, minimizing variability, and enhancing therapeutic efficacy.
(4) Quality control (QC) and regulatory compliance: Regulatory agencies such as the FDA and EMA require rigorous characterization of AAV vectors, including titer determination, to ensure safety and efficacy.
Creative Biogene, a biotechnology company focused on gene delivery solutions, has developed a comprehensive range of AAV titer detection kits designed to provide researchers with accurate and reliable AAV vector quantification. These kits are critical to ensuring the quality, consistency and reproducibility of AAV-based gene therapies.
The sandwich ELISA assay is a reliable technique for quantifying adeno-associated virus (AAV) capsid proteins, allowing researchers to determine viral titers with high specificity and sensitivity. Creative Biogene has developed a range of AAV titer ELISA kits designed to detect and quantify AAV capsid proteins of different AAV serotypes. Key advantages include:
| Cat.No. | Product Name | Price |
|---|---|---|
| ATDK0001 | AAV1 Titration ELISA Kit | Inquiry |
| ATDK0002 | AAV2 Titration ELISA Kit | Inquiry |
| ATDK0003 | AAV3 Titration ELISA Kit | Inquiry |
| ATDK0004 | AAV5 Titration ELISA Kit | Inquiry |
| ATDK0005 | AAV6 Titration ELISA Kit | Inquiry |
| ATDK0006 | AAV8 Titration ELISA Kit | Inquiry |
| ATDK0007 | AAV9 Titration ELISA Kit | Inquiry |
Creative Biogene's AAV qPCR Titer Kit is a kit for the determination of adeno-associated virus (AAV) titers using real-time PCR. It offers a simplified one-step protocol with no digestion step required. The kit has high sensitivity and specificity, minimizing nonspecific background, resulting in better performance than comparable kits. The quantitative analysis is based on the amplification of the ITR (inverted terminal repeat) of AAV, so titers of various AAV serotypes can be determined. Key advantages include:
| Cat.No. | Product Name | Price |
|---|---|---|
| ATDK0008 | AAV qPCR Titer Kit | Inquiry |
Creative Biogene's AAV titer detection kits provide researchers with a reliable, high-precision AAV vector quantification tool to ensure the successful development of gene therapy from bench to bedside. Whether used for research, preclinical trials or large-scale production, our kits provide the accuracy and consistency needed to advance the field of gene therapy.
Copyright © Creative Biogene. All rights reserved.