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DNA can be modified by methylation of cytosine bases, particularly cytosines preceding guanines (CpG dinucleotides), by enzymes called DNA methyltransferases. This epigenetic modification generally functions to repress gene expression and is important for the regulation of cellular differentiation and development. DNA methylation can also serve as an epigenetic biomarker for many human diseases, especially in cancer. Creative Biogene studied the chemistries involved in the process and the conversion rates in an effort to limit variability between samples and to improve yield over the conventional methods.