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Membranes, or phospholipid bilayers, which are electrical insulators, build a hydrophobic, low dielectric barrier to hydrophilic and charged molecules. Ion channels are a sort of membrane protein complexes. Their function is to facilitate the diffusion of ions across biological membranes. Ion channels provide a high conducting, hydrophilic pathway across the hydrophobic interior of the membrane. Ion channels act as gateways which allow ions to travel through them to respond to multiple signal events. And they are approved to regulate a wide variety of processes important to ionic homeostasis.
To obtain more specific biophysical and pharmacological analysis, scientists simplify ion channels by expressing it in cultured, non-neuronal cell lines. Creative Biogene has the most extensive collection of cell lines stably expressing functional ion channels, including Nav, Cav, ERG and others. These cell lines are carefully selected for optimal performance thus ensuring a high level of accuracy and precision in the assays. Our experienced scientists will provide researchers with extensively optimized and validated ion channel stable cell lines for your electrophysiology experiments.