Creative Biogene is a leading biotechnology company offering the best phosphatases services. With years of experience and expertise in phosphatase compounds drug discovery, our talented scientists will work closely with you to provide any help in phosphatases screening and profiling services.
Fig.1 The structure of alkaline phosphatase
Creative Biogene runs a wide range of fluorescence-based phosphatase assays and offers high throughput screening or compounds profiling against a selection of protein phosphatases, meantime, we can also validate new phosphatase targets based on your request. Moreover, high-quality of HTS, single concentration studies and IC50 determination services will be also provided by us. Through the combined expertise of our different platforms and services, Creative Biogene has developed a robust, reliable, stable and well-characterized solution to screen your focused compound libraries or profile your lead compounds for their inhibitory effects on phosphatases.
Protein phosphorylation is vital for normal cellular function and a major control mechanism of a wide range of physiological processes. Phosphate groups are post-translational modifications that regulate many disease states, including cancers, neurological diseases, diabetes, pain, autoimmune disorders, and cardiovascular diseases. Actually, protein phosphorylation-mediated signaling events offer plenty therapeutic targets, and drug discovery efforts to date have brought over two dozen kinase inhibitors to the clinic (He et al. 2014). As a result, the responsible modifying enzymes, like phosphatases, have been a focus of therapeutic modulation, with the hopes of improving human health.
Fig.2 The model picture for phosphatases, diseases and drugs (Sofie De et al. 2012)
Creative Biogene offers phosphatase compounds screening and profiling services which will save your time and cost, and accelerate your drug discovery program. Advantages of phosphatase screening and profiling in Creative Biogene:
More than 20 available assays for selectivity profiling of novel compounds
Years of experience in phosphatase drug profiling
Rapid turnaround time
Low level for both false positive and false negatives
Creative Biogene is an innovative and reliable partner in your research. Creative Biogene is dedicated to ensuring our services on phosphatases profiling are at the highest level of quality. Our experienced scientists are dedicated to identifying the compounds with the greatest chance to succeed. Meantime, based on the commitment of prompt communication and on-time reporting, our staffs will ensure a high-efficiency service to meet the strict project timelines.
If you have any special requirements in phosphatases compound screening, please feel free to contact us at firstname.lastname@example.org or 1-631-626-9181. We are looking forward to working together with your attractive projects.
He, R., Yu Z, Zhang, R., Zhang, Z. (2014) ‘Protein tyrosine phosphatases as potential therapeutic targets’, Acta Pharmacologica Sinica, 35, 1227–1246
Sofie De, M., Maja, K., Mathieu, B. (2012) ‘Challenges and Opportunities in the Development of Protein Phosphatase-Directed Therapeutics’, ACS Chem. Biol., 8, 36−45