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dsRNA Synthesis Service

Creative Biogene is a leading biotechnology company which has the expertise and ability in providing dsRNA synthesis service for customers worldwide. Creative Biogene's sophisticated equipments, advanced technologies and highly experienced staffs are available to produce any dsRNA ranging from 150-2000 bps in length. Creative Biogene’s goal is to provide you with the most affordable, high-quality dsRNA synthesis service to ensure your satisfaction in a timely and professional manner.

dsRNA Synthesis ServiceFig.1 Diagrammatic representation of mechanism of RNAi.[2]

Double-stranded RNA (dsRNA) is an important regulator of gene expression in many eukaryotes. It triggers different types of gene silencing that are collectively referred to as RNA silencing or RNA interference (RNAi). During the occurrence of RNAi, dsRNA is cleaved into short RNA duplexes of 21 to 28 nucleotides in length, which then guide the recognition and ultimately the cleavage or translational repression of complementary single-stranded RNAs, such as messenger RNAs or viral genomic/antigenomic RNAs. The short RNAs have also been implicated in guiding chromatin modification. The phenomenon of RNAi as a method for gene silencing may be used for large-scale screens that systematically shut down each gene in the cell, which can help to identify the components necessary for a particular cellular process or an event. The pathway is also used as a practical tool in biotechnology, medicine, insecticides, plant development, and germplasm improvement. Since small dsRNAs are required for various RNAi applications, there is a need for producing large quantities of high-quality dsRNA.

Creative Biogene, as a leading biotechnology company in the world, is able to offer the dedicated service for the synthesis of high quality dsRNA to customers worldwide. With our unparalleled expertise and experience in dsRNA synthesis, Creative Biogene has confident to help you carry out your specific project as cost effectively and quickly as possible, without compromising on quality. If you have any special requirements in our dsRNA synthesis service, please feel free to contact us at or 1-631-626-9181. We are looking forward to working together with your attractive projects.

References:

  1. Meister G. & Tuschl T. (2004). Mechanisms of gene silencing by double-stranded RNA. Nature, 431(7006), 343-349.
  2. Younis A. et al, (2014). RNA interference (RNAi) induced gene silencing: a promising approach of hi-tech plant breeding. International journal of biological sciences, 10(10), 1150.
  3. Agrawal N. et al. (2003). RNA interference: biology, mechanism, and applications. Microbiology and molecular biology reviews, 67(4), 657-685.
For research use only. Not intended for any clinical use.

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