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Self-Complementary AAV (scAAV) Particles

Self-complementary adeno-associated virus (scAAV) contains a dimeric inverted repeat genome able to fold into double stranded DNA (dsDNA).

scAAV particles possess several advantages compared with traditional single-stranded AAV (ssAAV). Previous studies have shown increased and prolonged transgene expression in vitro and in vivo using scAAV. Additional advantage of scAAV is that it can infect a variety of cellular targets by using different serotypes. In addition, scAAV allows higher in vivo DNA stability and more effective circularization.

Two disadvantages may restrict scAAV application in gene therapy. First, the cargo capacity of scAAV is lower than ssAAV, which is ~2.4 kb vs ~4.7 kb. Second, the robust gene expression efficiency may elicit a stronger immune response in vivo.

Although the existing of above restrictions, scAAV has become an attractive vector for use in gene therapy. Creative Biogene is offering prepackaged scAAV particles that could save your time and cost. If you could not find a product of interest, please contact us for a custom service.


  1. McCarty DM, Monahan PE, Samulski RJ. (2001) “Self-complementary recombinant adeno-associated virus (scAAV) vectors promote efficient transduction independently of DNA synthesis”. Gene Ther. 8(16):1248-54.

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For research use only. Not intended for any clinical use.