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Immune checkpoints are critical regulators of immune activation, tolerance, and exhaustion. Recombinant immune checkpoint proteins serve as indispensable tools for investigating immune signaling pathways, evaluating receptor–ligand interactions, and supporting immuno-oncology research workflows.
Our Immune Checkpoint recombinant protein portfolio is developed to provide reliable, application-ready reagents for immune checkpoint research, with an emphasis on functional integrity, experimental reproducibility, and broad species coverage.
Immune checkpoint proteins are widely applied across both fundamental immunology and translational research settings. This portfolio is designed to support common experimental workflows encountered in immune regulation and immunotherapy-related studies.
Immune Activation and Inhibitory Signaling Studies
Checkpoint receptors and ligands are essential for investigating immune activation thresholds, inhibitory signaling mechanisms, and immune exhaustion states under physiological and disease-relevant conditions.
Receptor–Ligand Interaction Analysis
Recombinant immune checkpoint proteins are suitable for studying checkpoint pathway interactions using biochemical and biophysical approaches, supporting binding characterization and pathway validation.
Antibody Discovery and Characterization
Immune checkpoint proteins serve as well-defined antigens for antibody screening, specificity assessment, and affinity evaluation, supporting antibody discovery and preclinical research programs.
Cell-Based Functional Assays
These proteins are widely used in the development and calibration of cell-based assays, including reporter systems and immune signaling studies, enabling controlled evaluation of checkpoint-related pathways.
Immuno-Oncology Research Support
Checkpoint proteins are routinely applied in immuno-oncology research workflows, including target evaluation, pathway comparison, and translational research model development.
The portfolio includes a broad range of immune checkpoint receptors and ligands involved in immune activation, inhibition, and co-stimulation, supporting diverse experimental needs.
Coverage includes:
This comprehensive coverage enables flexible selection of checkpoint targets across discovery-stage and preclinical research workflows.
Immune checkpoint proteins are designed to preserve biologically relevant domains and native-like conformations, supporting accurate receptor–ligand interactions and functional assay performance.
Expression systems are selected to facilitate correct protein folding, appropriate post-translational modifications, and structural stability, particularly for immune checkpoint molecules with complex extracellular architectures.
Construct options, including different fusion formats, are available to support diverse assay requirements and experimental designs.
Consistent performance is essential for immune checkpoint research, where subtle differences in binding or signaling can significantly impact experimental outcomes. Each recombinant protein is produced under standardized quality control processes designed to support reliable and reproducible results.
Key quality attributes include:
The Immune Checkpoint recombinant protein portfolio is supplied for research use only and is designed to support both discovery-stage and translational research programs. Broad target coverage, multiple construct formats, and application-oriented quality control enable flexible integration into diverse experimental workflows. For detailed product specifications, available formats, or technical support, please explore individual product pages or contact our technical support team.
| Cat.No. | Product Name | Price |
|---|---|---|
| RP00013 | Recombinant Human BTLA (C-6His) | Inquiry |
| RP00015 | Recombinant Cynomolgus TIGIT (C-6His) | Inquiry |
| RP00031 | Recombinant Human TIGIT (C-Fc) | Inquiry |
| RP00035 | Recombinant Human TIGIT (C-6His) | Inquiry |
| RP00043 | Recombinant Human CD47 (C-6His) | Inquiry |
| RP00073 | Recombinant Cynomolgus CD96 (C-Fc) | Inquiry |
| RP00077 | Recombinant Cynomolgus CD96 (C-6His) | Inquiry |
| RP00082 | Recombinant Mouse PD-L2 (C-6His) | Inquiry |
| RP00086 | Biotinylated Mouse PD-L2 (C-Avi-6His) | Inquiry |
| RP00101 | Recombinant Cynomolgus CD96 (C-Fc) | Inquiry |
| RP00102 | Recombinant Cynomolgus CD96 (C-6His) | Inquiry |
| RP00112 | Recombinant Cynomolgus CD96 (C-6His) | Inquiry |
| RP00130 | Recombinant Mouse CD47 (C-6His) | Inquiry |
| RP00133 | Recombinant Human ICOS (C-Fc) | Inquiry |
| RP00150 | Recombinant Human BTLA (C-Fc) | Inquiry |
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