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circRNA-miRNA/RBP Interaction Analysis Service

Creative Biogene has developed a complete workflow for your circRNA-miRNA or circRNA-RNA banding protein (RBP) interaction analysis, which has been enhanced with the latest technologies. We offer affordable and high-quality circRNA interaction analysis services for customers. From target miRNA discovery to confirmation and interacting protein screening to validation, our innovative portfolio of circRNA analysis will help you gain more insights and make the most impact with your research program.

circRNA is a novel type of endogenous noncoding RNA that has gained attention from researchers for its involvement in multiple biological processes. It is reported that circRNA acts as miRNA sponge and RBP sponge to function in human diseases. For example, ciR-7 contains more than 70 selectively conserved miRNA target sites that can bind miR-7, facilitate a specific miR-7-AGO2 interaction, and suppress miR-7 activity in diseases including hepatocellular carcinoma, colorectal cancer and diabetes.

Schematic diagram of circRNA functioning as miRNA/RBP sponge Fig 1. Schematic diagram of circRNA functioning as miRNA/RBP sponge

Creative Biogene emlpoys dual luciferase reporter assay system to validate the sponge function of circRNA and detect target miRNA. This sensitive and efficient assay method is suitable for most cell types. To analysis the interaction between circRNA and RNA banding protein, Creative Biogene establishes a powerful interaction analysis system based on RNA pull-down assay and RNA immunoprecipitation (RIP) technology. Our excellent interaction analysis system can efficiently screen and validate banding protein to accelerate you research program.

Creative Biogene is a leading biotechnology company, which has the expertise and ability in providing circRNA-miRNA/RBP interaction analysis service for customers worldwide. Based on our sophisticated equipment, advanced technology and experienced staff, we will assist you with the most affordable and high-quality service to ensure your satisfaction in a timely and professional manner.

If you have any requirements in our circRNA-miRNA/RBP interaction analysis service, please feel free to contact us at or 1-631-626-9181. We are looking forward to working together with your attractive projects.

Reference:

  1. Xiang, L. (2018). The biogenesis, functions, and challenges of circular rnas. Molecular Cell, S1097276518305094-.

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