iPS Adenovirus Particles

Somatic cells can be transformed into induced pluripotent stem (iPS) cells by transduction of transcription factors Sox2, c-Myc, Klf4 and Oct4. The iPSC technology avoids the ethical problems involved in human embryonic stem (ES) cell research. Traditional method uses the retrovirus or lentivirus for transducing reprogramming factors into somatic cells. However, these viruses can integrate into host cell genome which may cause mutation and interfere with gene transcription. To overcome the integration issue, replication-defective adenoviral vectors have been used to produce iPS cells. Several studies have successfully produced iPS cells using adenoviral vectors without any viral or transgene integration into chromosomal DNA.

Creative Biogene provides adenoviral vectors expressing various transcription factors that are commonly used in development of iPS cells such as c-Myc, Klf4, Oct4, and Sox2.

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