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Premade mRNA Products
Fig.1 Potential therapeutic applications of IVT mRNA. [1]
Messenger RNA (mRNA) is a single-stranded RNA molecule that is complementary to one of the DNA strands of a gene. The mRNA is an RNA version of the gene that transfers the information from the cell nucleus to the cell machinery that makes proteins. During decades of intense research in molecular biology and biochemistry, mRNA has gained great interest as a therapeutic agent. mRNA synthesized by in vitro transcription (IVT) methods, can be sequence optimized to improve translatability into proteins, as well as chemically modified to reduce immunogenicity and increase chemical stability using naturally occurring uridine modifications. In addition, synthetic mRNA also has some other advantages, e.g., the lack of risk for genomic integration, or the expression of the encoded protein in the cytoplasm without the need to cross the nuclear membrane. All these features make IVT mRNA a powerful alternative gene expression system for various applications including regenerative medicine, vaccination, the treatment of hereditary diseases and tumors, and cell engineering.
Creative Biogene, as a leading biotechnology company in the world, is able to offer a series of premade mRNA products to satisfy your various downstream applications. With our sophisticated equipments, advanced technologies and highly experienced staffs, Creative Biogene has confident to provide you with the most affordable and high-quality premade mRNA products to ensure your satisfaction in a timely and professional manner. If you have any special requirements in our mRNA products, please feel free to contact us at info@creative-biogene.com. We are looking forward to working together with your attractive projects.
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References:
- Sahin U., et al. (2014). mRNA-based therapeutics—developing a new class of drugs. Nature reviews Drug discovery, 13(10), 759-780.
- Steinle H., et al. (2017). Concise review: application of in vitro transcribed messenger RNA for cellular engineering and reprogramming: progress and challenges. Stem Cells, 35(1), 68-79.
- Vallazza B., et al. (2015). Recombinant messenger RNA technology and its application in cancer immunotherapy, transcript replacement therapies, pluripotent stem cell induction, and beyond. Wiley Interdisciplinary Reviews: RNA, 6(5), 471-499.
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Creative Biogene is a US-based manufacturer and provider of genomics and proteomics products and services for academic and governmental research institutes, pharmaceutical and biotechnology industry.
