HEK293 Cell-Based Production Platform

CRDMO Services for Viral Vector & Protein Production

Creative Biogene provides end-to-end contract research, development, and manufacturing (CRDMO) services built on a foundation of intellectual property clarity and technical excellence. Our formal, worldwide commercial license from AdVec™ Inc. for the HEK293 cell line family ensures your viral vector, vaccine, or therapeutic protein project begins and ends with complete legal and commercial freedom.

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Why HEK293?

The HEK293 cell line is the gold standard for transient and stable expression, renowned for its high transfection efficiency, robust growth, and ability to produce complex proteins and viral vectors with proper post-translational modifications.

Advantages of our HEK293-based Production Platform:

We hold an active, global non-exclusive commercial license from AdVec™ Inc., the recognized IP holder, granting us the rights to use the proprietary HEK293 cell line and its derivatives for both research and commercial applications.

Freedom to Operate

Your project utilizes a cell platform with cleared underlying IP, mitigating a critical legal risk for product commercialization.

Direct from the Source

Our license originates from the laboratory of Dr. Frank L. Graham, co-creator of the HEK293 cell lines, ensuring authenticity.

Commercial Rights Included

The license covers the commercial use of biological materials (viruses, vectors, proteins) produced using the licensed HEK293 cells.

Core CDMO Services on the Licensed HEK293 Production Platform

Leveraging our licensed HEK293 and adapted suspension (e.g., 293N3S) cell lines, we offer comprehensive development and manufacturing services.

Viral Vector Manufacturing

Lentiviral (LV) Vectors: For CAR-T, gene therapy, and cell engineering applications.
Adeno-Associated Viral (AAV) Vectors: Serotype-specific process development and GMP manufacturing for in vivo gene therapy.
Virus-Like Particles (VLPs): For vaccine candidates, delivery tools, and diagnostics.
Other Viral Vectors: Including adenovirus (AdV), Retrovirus, and oncolytic viruses.

Recombinant Protein & Antibody Expression

Transient Gene Expression: Rapid, high-yield production of recombinant proteins, antibodies, enzymes, and antigens for research, screening, and pre-clinical studies.
Stable Cell Line Development: Generation of clonal, high-producing cell lines for your therapeutic protein or antibody to support long-term manufacturing needs.

Cell Line Services & Licensing Support

Sublicensing Support: We can assist clients in structuring compliant sublicensing arrangements for specific products developed using this platform.
Custom cell line engineering and development based on client-specific requirements.

Why Partner With Us?

Combining Legitimacy with Expertise

Key Differentiator	What It Means for Your Project
Validated Legal Foundation	Our direct license from AdVec™ provides IP certainty for the core production platform, securing your commercialization path.
End-to-End Solutions	From cell banking and process development to analytical testing, scale-up, and cGMP manufacturing.
Platform Expertise	Deep experience in HEK293 culture optimization, transfection, and downstream processing to maximize titers and quality.
Quality & Compliance	Development aligned with ICH Q7, Q8, Q9, Q10, and Q11 principles, supported by robust quality systems for clinical and commercial supply.
Confidential Collaboration	Protection of your IP is paramount, governed by strict confidentiality agreements and secure data management.

Accelerate your biotherapeutic development with a partner built on a licensed, reliable foundation.

Consultation

We discuss your molecule, goals, and timeline.

Proposal

We provide a tailored technical and commercial proposal based on our licensed platform.

Agreement

We align on scope, deliverables, and terms.

Execution

Our dedicated team executes the project with transparent communication.

Delivery

We supply high-quality materials and comprehensive documentation.

Contact us now to discuss how our HEK293-based CDMO services can advance your program.

Footer Note:

Services described are offered under our executed License Agreement with AdVec™ Inc. Clients are responsible for ensuring the compliance of their specific products with all other applicable intellectual property rights. "AdVec" and related marks are trademarks of AdVec™ Inc.

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