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Creative Biogene is a world-leading biotechnology company specializing in screening and profiling for phosphatase, especially for serine/threonine phosphatase. Our best-in-class compounds screening platform can significantly advance customers’ drug development programs by offering high-quality and comprehensive service. With years of experience and expertise in this field, we will assist your project with accurate data and fast turnaround time.
Creative Biogene establishes a high efficient biochemical and cell-based screening system to select candidate substrates, inhibitors or activators of serine/threonine phosphatase (STPT). We offer a wide range of STPT screening, covering from PP1, PP2A, PP2B, PP5, PP6 and PP2C. Our comprehensive screening services will ensure the discovery and identification of novel drug targets for you.
Table 1. Small-molecular effector of validated STPT drug targets
|PPP superfamily||PP1||PDP3, 1H4, CP-320626||Cancer, HIV, diabete|
|PP2B||Cyclosporin A and FK506||Organ transplant rejection|
|PP5||Chaulmoogric acid||Alzheimer’s disease|
|PPM superfamily||PP2Cα||NPLC 0393||liver fibrosis|
Serine/threonine phosphatases(STPTs) are metal-requiring enzymes that regulate many pathways involved in cell proliferation, programmed cell death (apoptosis), embryonic development, and cell differentiation. STPT, which is divided into phosphoprotein phosphatase (PPP) superfamily and magnesium /manganese-dependent protein phosphatase (PPM) superfamily, becomes critical target for various diseases treatment. Hence, the development of STPT activators and inhibitors has become a research hotspot in targeted therapy area.
Fig 1. Serine/threonine Phosphatase Structure. (PP2C)
Creative Biogene utilizes the superior technology to quickly narrow down a large pool of candidates to a much smaller one and accelerates the discovery of lead compounds. Our team of experts are able to provide the following STPT assay services:
Advantages of STPT screening:
Creative Biogene provides a comprehensive list of HTS services to identify potential targets of STPT. In addition, we offer availability of various panels of STPT for your inhibitor or activator identification. Based on proper communication and updated project progress on time, Creative Biogene is dedicated to accelerating your drug discovery program with high-quality and short lead time.
If you have any requirements in serine/threonine phosphatase screening, please feel free to contact us at email@example.com or 1-631-626-9181. We are looking forward to working together with your attractive projects.