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CpG Oligodeoxynucleotides Synthesis Service

Creative Biogene is a leading biotechnology company which has the expertise and ability in providing CpG oligodeoxynucleotides synthesis service for customers worldwide. Creative Biogene's sophisticated equipments, advanced technologies and highly experienced staffs are available to assist you synthesis your interested CpG oligodeoxynucleotides. Creative Biogene’s goal is to provide you with the most affordable, high-quality CpG oligodeoxynucleotides synthesis service to ensure your satisfaction in a timely and professional manner.

CpG oligodeoxynucleotides (CpG ODN) is a synthetic oligodeoxynucleotide, containing unmethylated CpG motifs derived from bacterial DNA, with immunostimulatory activities. Several studies have shown that CpG ODN is able to stimulate cells that express TLR9, initiating an immunomodulatory cascade that culminates in the production of Th1 and proinflammatory cytokines and chemokines. Besides, they also can improve the antigen presenting function of dendritic cells, monocytes and macrophages, induce the proliferation of B cells, stimulate the immunoprotective activity of NK cells, and recruit T cells to the site of ODN administration. These diverse effects of CpG ODN on the host's immune milieu underlie their value as vaccine adjuvants, indicate that CpG ODN has great promise to act as immunotherapeutic agent for treatment of infectious diseases, allergy and cancer.

CpG-Oligodeoxynucleotides-Synthesis-Service.jpgFig. 2 Immunostimulatory effect of CpG ODNs. [2]

So far three major classes of CpG ODNs have been identified, based on their structural and biological characteristics, and are designated Type A, Type B, and Type C. Type A ODNs, which feature a central palindromic CpG-containing phosphodiester (PO) structure followed by a phosphorothioate (PS) homopolymeric G-stretch, are robust inducers of interferon-α (IFN-α) production and dendritic cell maturation. Type B ODNs, in contrast, contain a full phosphorothioate backbone with one or more CpG dinucleotides. They strongly activate B cells but stimulate weakly IFN-α secretion. Type C ODNs, combine the properties of both Type A and B, and are characterized by their complete PS backbone and palindromic CpG-containing motifs. Type C ODNs induce strong IFN-α production from pDC and B cell stimulation.

With years of development, Creative Biogene now possesses extensive expertise and experience which is able to help you synthesis high-quality CpG oligodeoxynucleotides, including type A ODNs, type B ODNs and type C ODNs, to accelerate the speed to achieve your research goals. If you have any special requirements in the CpG oligodeoxynucleotides synthesis service, please feel free to contact us at info@creative-biogene.com or 1-631-626-9181. We are looking forward to working together with your attractive projects.

References:

  1. Klinman DM, et al. (2009). CpG oligonucleotides as adjuvants for vaccines targeting infectious diseases. Advanced drug delivery reviews, 61(3), 248-255.
  2. Zhang H, & Gao XD. (2017). Nanodelivery systems for enhancing the immunostimulatory effect of CpG oligodeoxynucleotides. Materials Science and Engineering: C,70, 935-946.

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