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circRNA Functional Analysis

Creative Biogene provides incomparable circRNA functional analysis service for customers worldwide. Our experienced scientists are available to assist you to reveal the biological function of circRNA through several strategies, including circRNA-FISH, circRNA inhibition and circRNA overexpression. Our one-stop service for circRNA functional analysis will facilitate your research project and explore the potential clinical applications of circRNA.

The recent researches reveal that circRNAs are evolutionarily conserved across plants, animals, and human beings, and have important biological functions like miRNA sponge, RBP sponge, alternative splicing, transcriptional/post-transcriptional gene regulation. Therefore, it is especially important to study the function of circRNA.

Potential Functions of circRNAs Fig 1. Potential Functions of circRNAs

Comprehensive detection of circRNAs from high-throughput data is the first step to study their biogenesis and function. After obtaining candidate circRNA through RNA-seq, microarray and bioinformatics analysis, it is necessary to confirm its localization and manipulate its expression to further elucidate the biological function of circRNA. FISH service offered by Creative Biogene can be used to detect and localize specific circRNA in cells, tissues and tumor samples, which establishes a foundation to reveal the function of circRNA. In addition, Creative Biogene also provides circRNA inhibition and overexpression services to efficiently downregulate/upregulate the expression of circRNA and investigate the molecular mechanism of circRNA in cancer cell proliferation and apoptosis. It has a promising prospect in treating disease that are resultant of incorrect regulation of circRNA.

Advantages of Creative Biogene

  • Accurate subcellular localization of circRNA
  • Efficient overexpression system: the expression level is hundreds of times higher than control
  • Specifically reduce the expression of circRNA and do not affect the host linear RNA expression
  • Quick turnaround time
  • Cost-effective

Based on fully-fledged experimental system and outstanding scientists, Creative Biogene is able to provide you with high-quality functional analysis service of circRNA. As a leading biotechnology company, Creative Biogene is a reliable partner that can work with you to accelerate the speed to achieve your research goals.

If you have any requirements in our circRNA functional analysis service, please feel free to contact us at or 1-631-626-9181. We are looking forward to working together with you.

Reference:

  1. Barrett, S. P. (2016). Circular RNAs: analysis, expression and potential functions. Development, 143(11), 1838-1847.

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