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Creative Biogene is committed to providing high quality products and services to help scientists around the world find solutions in biological research and drug discovery.
Circular RNA (circRNA) is a unique type of noncoding RNA molecule. Compared with traditional linear RNA, circRNA is a covalently closed circle produced by a process called backsplicing. CircRNA is abundant in many cells and has rich functions in cells, such as acting as miRNA sponge, protein sponge, protein scaffold, and mRNA regulator.
RNA-based therapeutics are one of the most attractive classes of drugs for treating a variety of diseases. To function in vivo, RNA requires safe, effective and stable delivery systems that protect the nucleic acid from degradation and that allow cellular uptake and RNA release.
Significant progress has been made in circular RNA (circRNA) research in recent years. Increasing evidence suggests that circRNAs play important roles in many cellular processes, and their dysregulation is implicated in the pathogenesis of various diseases.
The delivery potential of oligonucleotides can be enhanced through direct covalent conjugation of various moieties that promote intracellular uptake, target the drug to specific cells/tissues or reduce clearance from the circulation. These include lipids (for example, cholesterol that facilitates interactions with lipoprotein particles in the circulation), peptides (for cell targeting and/or cell penetration), α-tocopherol, aptamers, antibodies, fatty acids and sugars (for example, N-acetylgalactosamine (GalNAc)).
Creative Biogene introduced customers to the application of Cas9 mRNA for gene editing and its potential for the future of genetic engineering.
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