Research Resource

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Research Areas

Research of KCNH2 Mutations in Arrhythmias

Functional and pathophysiological studies have led to better understanding of the clinical spectrum, ion channel structures and cellular electrophysiology involving dynamics of intracellular calcium cycling in many subtypes of these disorders.

Research of Thyrotropin/IGF-1 Receptor in Graves' Ophthalmopathy

Graves' orbitopathy (GO) is an inflammatory autoimmune disorder of the orbit. The immune basis of the disease is suggested by a perivascular and diffuse infiltration of CD4+ and CD8+ T cells, B cells, plasma cells and macrophages.

Research of HAVCR2 in Cancer Immunotherapy

Cancer immunotherapy is a type of cancer treatment using the body's own immune system to fight against cancer. Dr. William Coley is reported to be the first one pioneered the treatment of cancer with immunotherapy.

Research of Glucagon-Like Peptide 1(GLP-1) in The Treatment of Type 2 Diabetes(T2D)

Type 2 diabetes (T2D), the major type of diabetes mellitus (DM), is a long term metabolic disorder primarily occurs as a result of obesity and not enough exercise.[1] T2D is characterized by high blood sugar, insulin resistance, and relative lack of insulin.

Current Research and Role of A2A Receptors in Parkinson's Disease

The adenosine receptors (ARs) in the nervous system act as a kind of "go-between" to regulate the release of neurotransmitters and the action of neuromodulators. Receptor-receptor interactions and AR-transporter interplay occur as part of the adenosine's attempt to control synaptic transmission[1].

CTLA-4 and PD-1 Blockade in Cancer Immunotherapy

The potential of T cells to attack and destroy tumors has long been recognized. Recent experimental evidence has also demonstrated that T cell surveillance throughout the life of an organism functions to prevent tumor development.

Research of CD200 and CD200R in Inflammation and Tumor Tolerance

The main role of the immune system is to protect the organism against damage by ensuring an adequate response against various pathogens such as viruses, fungi, bacteria, parasites, environmental harm stimuli including allergens, haptens, and also from damage that may result from inappropriate immune system activation.

CCR5 as a Novel Therapy Strategies Based on Induction of Resistance to HIV

Human immunodeficiency virus (HIV), the causative agent of acquired immunodeficiency syndrome (AIDS), has become one of the most costly and deadly epidemics in human history. Once thought of as a death sentence, HIV infection has become a chronically manageable disease.

Research of Agonistic CD40 Antibodies in The Mechanism of Action of Cancer Immunotherapy

Immunotherapy is an emerging alternative or adjunct to traditional cancer therapies, its goal being to stimulate a potent and specific anti-tumor immune response. The agonistic anti-CD40 monoclonal antibody is one of the most promising immunotherapies tried so far in animal models.

* For research use only. Not intended for any clinical use.

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