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Research Resource

Creative Biogene is committed to providing high quality products and services to help scientists around the world find solutions in biological research and drug discovery.

Research Areas

The Applications of G Protein Coupled Receptor (GPCR) in Antidiabetic Drug Research and Development

Diabetes is a disease that seriously threatens human health, and type 2 diabetes makes up about 90% of cases of diabetes[1]. Type 2 diabetes is a long-term metabolic disorder that is characterized by high blood sugar, insulin resistance, and relative lack of insulin.

Research of TRPV1 in Drug Discovery: Targeting Pain and Other Pathological Disorders

Chronic pain affects a large segment of the population, an estimated 50 million Americans, and costs the country billions of dollars in health care costs and lost productivity. Although the Decade of Pain Control and Research has given new impetus to pain research, the translation of preclinical research into clinical practice is slow to occur.

Role of Sodium Channel in Atrial Fibrillation Pathophysiology and Therapy

Safe and effective treatment of atrial fibrillation (AF) remains a major unmet medical need in our society, and the problem is growing as the prevalence of AF continues to increase with the aging of the baby boom generation.

Role of G Protein-coupled Receptor (GPCR) in Neuropsychiatric Disorders: Focusing on Depression

Mood disorders and in particular major depression, remain one of the most prevalent psychiatric disorders with a lifetime prevalence rate over 16% and affects twice as many women as men.

Research of The Role of PD-1/PD-L1 Pathway in Cancer

Tumor cells can escape the immune surveillance and disrupt immune checkpoint of host in several methods, therefore, to avoid the elimination from the host immune system. Numerous pathways are utilized by cancers to up-regulate the negative signals through cell surface molecules.

MiRNAs: the Next Generation Drugs in Human Cancer

In the past few years, therapeutic microRNA (miRNA) is some of the most important biopharmaceuticals that are in commercial space as future medicines. The discovery of therapeutic miRNA is considered one of the most exhilarating and significant therapeutic breakthroughs in pharmaceutical development.

Research of Liver X Receptors in Cardiovascular Disease

The liver X receptors (LXRs) are pivotal regulators of lipid homeostasis in mammals. These transcription factors control the expression of a battery of genes involved in the uptake, transport, efflux and excretion of cholesterol in a tissue-dependent manner.

LAG-3 in Cancer Immunotherapy

Cancer immunotherapy can reverse tumor immune escape by suppressing immune checkpoint pathways. It is possible that the inhibition of pathway checkpoints, including CTLA4, PD1 and PDL1, could activate T cells to attack and eliminate cancer.

Research of KCNH2 Mutations in Arrhythmias

Functional and pathophysiological studies have led to better understanding of the clinical spectrum, ion channel structures and cellular electrophysiology involving dynamics of intracellular calcium cycling in many subtypes of these disorders.

Research of Thyrotropin/IGF-1 Receptor in Graves' Ophthalmopathy

Graves' orbitopathy (GO) is an inflammatory autoimmune disorder of the orbit. The immune basis of the disease is suggested by a perivascular and diffuse infiltration of CD4+ and CD8+ T cells, B cells, plasma cells and macrophages.

* For research use only. Not intended for any clinical use.
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