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nucleic acid aptamers have become an important class of synthetic ligands with broad potential across biomedical research and therapeutic development. Derived entirely through in vitro selection, these single-stranded oligonucleotides can fold into defined three-dimensional structures that enable high-affinity and high-specificity binding to a wide range of molecular targets. Continuous refinements in SELEX methodology, coupled with advances in chemical modification and screening technologies, have transformed aptamer research from a conceptual framework into practical biomedical applications.
Cancer immunotherapy is a type of cancer treatment using the body's own immune system to fight against cancer. Dr. William Coley is reported to be the first one pioneered the treatment of cancer with immunotherapy.
Natural killer (NK) cells are a type of lymphocyte critical to the innate immunity. The critical role of NK cells involves rapid defense against pathogen infections, tumor cells and damaged cells. Unlike adaptive immune cells, NK cell-mediated killing do not require prior sensitization or antigens presented on targets.
Ovarian cancer (OC) is estimated to be diagnosed in over 225, 000 women per year worldwide and remains a significant cause of gynecological cancer mortality (approximately 140, 000 deaths per year).
GRKs (G-protein-coupled- receptor kinases) are a family of serine/threonine kinases traditionally known for their ability to recognize and phosphorylate agonist-activated G-protein-coupled receptors (GPCRs), leading to their desensitization.
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