Research Resource

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Research Areas

Utility of the Ba/F3 Cell System for Exploring On‐target Mechanisms of Resistance to Targeted Therapies for Lung Cancer

The development and approvals of targeted drugs have improved treatment outcomes of patients with NSCLC harboring driver mutations. This progress in oncology is encouraging; however, mechanistic analyses of acquired resistance to these targeted drugs is necessary to further improve patient outcomes.

A Case Study of Targeted FLT3 in The Treatment of Acute Myeloid Leukemia

Acute myeloid leukemia (AML), a malignant clonal disorder of the hematopoietic system, is characterized by an enormous heterogeneity of acquired genetic and epigenetic changes in hematopoietic precursor cells and by impaired mechanisms of proliferation, differentiation, and self-renewal.

TRPV1 in Drug Discovery: Targeting Pain and Other Pathological Disorders

TRPV1, the founding member of the 'vanilloid' TRP subfamily, is formerly known as the vanilloid receptor VR1. Vanilloid, because of its archetypal activators, capsaicin and resiniferatoxin, shares a vanillyl moiety essential for bioactivity.

Research on The Application of NK Cells in Cancer Immunotherapy

Natural killer (NK) cells are a type of lymphocyte critical to the innate immunity. The critical role of NK cells involves rapid defense against pathogen infections, tumor cells and damaged cells. Unlike adaptive immune cells, NK cell-mediated killing do not require prior sensitization or antigens presented on targets.

Research of CXCL12/CXCR4 Axis in Cancer Management

Chemokines are a family of cytokines which can induce gradient-dependent directional chemotaxis and are secreted by a variety of stromal and epithelial cells. These small proteins (8–10 kDa) have a common structural feature of conserved cysteine residues at the N-terminus.

Research on The Role of GRK5 in Cancer Development and Progression

GRKs (G-protein-coupled- receptor kinases) are a family of serine/threonine kinases traditionally known for their ability to recognize and phosphorylate agonist-activated G-protein-coupled receptors (GPCRs), leading to their desensitization.

Research of The Role of Follicle-Stimulating Hormone Receptors in The Treatment of Ovarian Cancer

Ovarian cancer (OC) is estimated to be diagnosed in over 225, 000 women per year worldwide and remains a significant cause of gynecological cancer mortality (approximately 140, 000 deaths per year).

Research of The Role of CACNA1C in The Pathophysiology of Psychiatric Disorders

CACNA1C is one of the most universally reproduced risk genes for neuropsychiatric disorders including bipolar disorder, schizophrenia, and major depressive disorder.

The Applications of G Protein Coupled Receptor (GPCR) in Antidiabetic Drug Research and Development

Diabetes is a disease that seriously threatens human health, and type 2 diabetes makes up about 90% of cases of diabetes[1]. Type 2 diabetes is a long-term metabolic disorder that is characterized by high blood sugar, insulin resistance, and relative lack of insulin.

Research of TRPV1 in Drug Discovery: Targeting Pain and Other Pathological Disorders

Chronic pain affects a large segment of the population, an estimated 50 million Americans, and costs the country billions of dollars in health care costs and lost productivity. Although the Decade of Pain Control and Research has given new impetus to pain research, the translation of preclinical research into clinical practice is slow to occur.

* For research use only. Not intended for any clinical use.

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