Research Resource

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Research Areas

Adaptor Protein Complex Interaction Map in Arabidopsis Identifies P34 as A Common Stability Regulator

Transport and distribution of biomolecules between plant cell endomembrane systems are essential for plant growth and development. Adaptor Protein (AP) is an evolutionarily very conserved class of complexes that are involved in the fine regulation of endosomal transport in plants.

Research on The Regulatory Mechanism of Manganate Pathway to Enhance Plant Carbon Dioxide Conversion

Terrestrial plants can convert atmospheric CO₂ into diverse and abundant aromatic compounds, thus providing high-value chemicals and considerable promise for carbon storage.

Human Adenovirus Serotype 5 Is Sensitive to IgM-Independent Neutralization In Vitro and In Vivo

Human adenoviruses have been used as gene therapy vectors. Amongst human adenoviruses, the most widely studied and used in gene therapy preclinical studies is human adenovirus 5 (HAdV-5).

Research of Genome-wide CRISPR Screening in Primary Human T Cells among Key Regulators of Immune Function

Cytotoxic T cells play a central role in immune-mediated control of cancer, infectious diseases, and autoimmunity. Genome-scale CRISPR screens in primary human T cells would enable comprehensive target discovery studies that could be rapidly translated into new immunotherapies with small molecules, biologics, and gene-engineered adoptive cell therapies.

Utility of the Ba/F3 Cell System for Exploring On‐target Mechanisms of Resistance to Targeted Therapies for Lung Cancer

The development and approvals of targeted drugs have improved treatment outcomes of patients with NSCLC harboring driver mutations. This progress in oncology is encouraging; however, mechanistic analyses of acquired resistance to these targeted drugs is necessary to further improve patient outcomes.

A Case Study of Targeted FLT3 in The Treatment of Acute Myeloid Leukemia

Acute myeloid leukemia (AML), a malignant clonal disorder of the hematopoietic system, is characterized by an enormous heterogeneity of acquired genetic and epigenetic changes in hematopoietic precursor cells and by impaired mechanisms of proliferation, differentiation, and self-renewal.

TRPV1 in Drug Discovery: Targeting Pain and Other Pathological Disorders

TRPV1, the founding member of the 'vanilloid' TRP subfamily, is formerly known as the vanilloid receptor VR1. Vanilloid, because of its archetypal activators, capsaicin and resiniferatoxin, shares a vanillyl moiety essential for bioactivity.

Research on The Application of NK Cells in Cancer Immunotherapy

Natural killer (NK) cells are a type of lymphocyte critical to the innate immunity. The critical role of NK cells involves rapid defense against pathogen infections, tumor cells and damaged cells. Unlike adaptive immune cells, NK cell-mediated killing do not require prior sensitization or antigens presented on targets.

Research of CXCL12/CXCR4 Axis in Cancer Management

Chemokines are a family of cytokines which can induce gradient-dependent directional chemotaxis and are secreted by a variety of stromal and epithelial cells. These small proteins (8–10 kDa) have a common structural feature of conserved cysteine residues at the N-terminus.

Research on The Role of GRK5 in Cancer Development and Progression

GRKs (G-protein-coupled- receptor kinases) are a family of serine/threonine kinases traditionally known for their ability to recognize and phosphorylate agonist-activated G-protein-coupled receptors (GPCRs), leading to their desensitization.

* For research use only. Not intended for any clinical use.

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