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Chemokines are a family of cytokines which can induce gradient-dependent directional chemotaxis and are secreted by a variety of stromal and epithelial cells. These small proteins (8–10 kDa) have a common structural feature of conserved cysteine residues at the N-terminus.
Acute myeloid leukemia (AML), a malignant clonal disorder of the hematopoietic system, is characterized by an enormous heterogeneity of acquired genetic and epigenetic changes in hematopoietic precursor cells and by impaired mechanisms of proliferation, differentiation, and self-renewal.
Type 2 diabetes (T2D), the major type of diabetes mellitus (DM), is a long term metabolic disorder primarily occurs as a result of obesity and not enough exercise.[1] T2D is characterized by high blood sugar, insulin resistance, and relative lack of insulin.
Diabetes is a disease that seriously threatens human health, and type 2 diabetes makes up about 90% of cases of diabetes[1]. Type 2 diabetes is a long-term metabolic disorder that is characterized by high blood sugar, insulin resistance, and relative lack of insulin.
The adenosine receptors (ARs) in the nervous system act as a kind of "go-between" to regulate the release of neurotransmitters and the action of neuromodulators. Receptor-receptor interactions and AR-transporter interplay occur as part of the adenosine's attempt to control synaptic transmission[1].
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