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| General Information | |
| Organism | Homo sapiens, human |
| Cell Line Description | PA-TU-8988S is a human pancreatic ductal adenocarcinoma cell line derived from a liver metastasis in a 64-year-old female patient. These cells exhibit an epithelial morphology and grow as an adherent monolayer under standard culture conditions. This cell line was isolated concurrently with its sister cell line, PA-TU-8988T; compared to the latter, PA-TU-8988S displays a highly differentiated phenotype and reduced invasive capacity. Genetically, PA-TU-8988S harbors driver gene alterations characteristic of pancreatic ductal adenocarcinoma, including mutations in the KRAS, TP53, and CDKN2A genes. Due to its well-defined phenotypic characteristics and paired origin, PA-TU-8988S serves as a valuable in vitro model for investigating the pathogenesis of pancreatic ductal adenocarcinoma, exploring the mechanisms of tumor cell differentiation and metastasis, evaluating the efficacy of targeted therapies and chemotherapeutic agents, and conducting functional genomic studies. |
| Tissue | Pancreas; derived from metastatic site (Liver) |
| Disease | Pancreatic Ductal Adenocarcinoma (PDAC); Pancreatic Cancer |
| Morphology | Epithelial |
| Gender | Female |
| Age | 64 years |
| Product Format | Frozen |
| Growth Mode | Adherent |
| Biosafety Level | 1 (Biosafety classification is based on U.S. Public Health Service Guidelines) |
| Applications | 1. Comparative study on the biological characteristics and metastatic potential of pancreatic ductal adenocarcinoma (PDAC); 2. In vitro screening and preclinical evaluation of targeted agents and chemotherapeutic drugs; 3. Research on pancreatic cancer cell differentiation, epithelial-mesenchymal transition (EMT), and motility; 4. Functional genomic analysis, target identification, and CRISPR/Cas9 knockout screening. |
| Shipped In | Dry ice |
| Storage Temperature | −196°C |
| Characteristics | |
| Karyotype | Aneuploid |
| Tumorigenic | Yes, tumorigenic in immunocompromised mice |
| Genetic Profile | KRAS mutation; TP53 mutation; CDKN2A alteration |
| Mycoplasma Test | Negative |
| Culture Conditions and Handling | |
| Subculturing | 1. Remove and discard the culture medium. 2. Briefly rinse the cell monolayer with PBS (without Ca2+/Mg2+) to completely remove residual serum. 3. Add 1.0 to 2.0 mL of 0.25% trypsin-0.03% EDTA solution and incubate at 37°C until the cell monolayer detaches (typically 3 to 6 minutes). 4. Add fresh complete growth medium to neutralize the trypsin and gently pipette up and down to create a single-cell suspension. 5. Subculture the cell suspension into new culture vessels. |
| Medium Renewal | Every 2 to 3 days |
| Subcultivation Ratio | A split ratio of 1:3 to 1:6 is recommended |
| Culture Conditions | Atmosphere: Air, 95%; CO2, 5%; Temperature: 37°C |
| Cryopreservation | Complete growth medium supplemented with 5% to 10% (v/v) DMSO |
| Cat.No. | Product Name | Price |
|---|---|---|
| CSC-RR0350 | GFP Reporter Cell Line - PA-TU-8988S | Inquiry |
| CSC-RO01541 | OVAL Stable Cell Line - PA-TU-8988S | Inquiry |
| CSC-RO01794 | GFP/OVAL Stable Cell Line - PA-TU-8988S | Inquiry |
| CSC-RO02047 | Luc/OVAL Stable Cell Line - PA-TU-8988S | Inquiry |
| CSC-RO02300 | GFP/Luc/OVAL Stable Cell Line - PA-TU-8988S | Inquiry |
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