Research Resource

Creative Biogene is committed to providing high quality products and services to help scientists around the world find solutions in biological research and drug discovery.

Research Areas

Overcoming Obstacles in Scaling Up Production of AAV-Based Gene Therapy

Creative Biogene presents to clients how successful applications in antibody production development translate into AAV to meet the challenges of scaling up their production.

Harnessing Self-Amplifying RNA Viruses Revolutionizing RNA Vaccines

Creative Biogene introduces customers to the basic functions of self-replicating RNA viral vectors and describes various pre-clinical and clinical applications.

Harnessing Ion Channels as Therapeutic Targets for Viral Infections

Creative Biogene presented to the client about the potential biological mechanisms of mRNA vaccines and their applications in a number of infectious diseases and cancers.

Clinical Perspectives and Recent Advances in mRNA Vaccines

Creative Biogene presented to the client about the potential biological mechanisms of mRNA vaccines and their applications in a number of infectious diseases and cancers.

Unlocking the Potential of Bioconjugation Enhancing Oligonucleotide Delivery

The delivery potential of oligonucleotides can be enhanced through direct covalent conjugation of various moieties that promote intracellular uptake, target the drug to specific cells/tissues or reduce clearance from the circulation. These include lipids (for example, cholesterol that facilitates interactions with lipoprotein particles in the circulation), peptides (for cell targeting and/or cell penetration), α-tocopherol, aptamers, antibodies, fatty acids and sugars (for example, N-acetylgalactosamine (GalNAc)).

The Rise of Circular RNA Therapeutics: Exploring Current Strategies and Overcoming Challenges

Significant progress has been made in circular RNA (circRNA) research in recent years. Increasing evidence suggests that circRNAs play important roles in many cellular processes, and their dysregulation is implicated in the pathogenesis of various diseases.

Lipid Nanoparticles as Promising RNA Delivery Vehicles

RNA-based therapeutics are one of the most attractive classes of drugs for treating a variety of diseases. To function in vivo, RNA requires safe, effective and stable delivery systems that protect the nucleic acid from degradation and that allow cellular uptake and RNA release.

Decoding the Synthesis of CircRNA: In Vitro Breakthroughs

Circular RNA (circRNA) is a unique type of noncoding RNA molecule. Compared with traditional linear RNA, circRNA is a covalently closed circle produced by a process called backsplicing. CircRNA is abundant in many cells and has rich functions in cells, such as acting as miRNA sponge, protein sponge, protein scaffold, and mRNA regulator.

Accelerating Drug Discovery with High-throughput Screening of Ion Channels

Ion channels are a very important membrane protein family involved in a variety of fundamental physiological processes. Their malfunction causes a variety of human diseases. Therefore, ion channels represent a class of attractive drug targets and a class of important off-targets for in vitro pharmacological profiling.

Unlocking the Potential Exploring Cellular Gene Knockout with CRISPR-Cas9 Technology

The field of bioscience research has been revolutionized by the emergence of CRISPR-Cas9 technology. This groundbreaking tool allows scientists to edit genes with unprecedented precision and efficiency, enabling them to unravel the mysteries of cellular processes and diseases.

* For research use only. Not intended for any clinical use.

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