Research Resource

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Research Areas

Exploring the Potential of CRISPRCas13-Mediated RNA Editing in Plants

The Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)/CRISPR-associated (Cas) system is widely used as a genome-editing tool in various organisms, including plants, to elucidate the fundamental understanding of gene function, disease diagnostics, and crop improvement.

Developed Strategies to Minimize the Off-Target Effects in CRISPR-Cas-Mediated Genome Editing

Clustered regularly interspaced short palindromic repeats (CRISPR)/Cas9 emerged as a substantial tool due to its simplicity in use, less cost and extraordinary efficiency than the conventional gene-editing tools...

cDNA Library Overview and Applications

cDNA libraries are crucial tools in molecular biology research. They provide a stable, manipulable copy of the mRNA content of cells, allowing researchers to investigate gene expression, splice variants, protein interactions and more. Unlike genomic DNA libraries, which include all of the DNA in an organism’s genome (including non-coding regions and introns), cDNA libraries include only those sequences that are transcribed into mRNA and potentially translated into proteins.

The Essential Principles of Constructing Knock-In Cell Lines and Key Details to Remember

Knock-in (KI) cell lines are crucial tools in biomedical research, predominantly used to model diseases, perform gene function analyses, and develop therapeutic strategies. Their construction involves integrating a specific allele or genetic alteration into a particular locus on the cell's chromosome.

Potential Applications of Adenovirus-Mediated Gene Delivery in Gene and Cell-Based Therapies

There has been a long-lasting interest in using viral vectors, especially adenoviral vectors, to deliver therapeutic genes for the past two decades. Among all currently available viral vectors, adenovirus is the most efficient gene delivery system in a broad range of cell and tissue types.

Innovations in Gene Editing: Use of Cas9 Viral Particles in CRISPR Delivery

To fully exploit the gene editing potential of CRISPR/Cas9, they must be efficiently introduced into target cells or tissues using appropriate vectors. Recombinant viral vectors have been developed using ability of viruses to transfer foreign genetic material into cells to deliver therapeutic genes to diseased tissues.

Clinical Prospects for Integrase-Deficient Lentivirus (IDLV)

HIV-1 derived lentiviral vector is an efficient transporter for delivering desired genetic materials into the targeted cells among many viral vectors. Genetic material transduced by lentiviral vector is integrated into the cell genome to introduce new functions, repair defective cell metabolism, and stimulate certain cell functions.

The Key to Moving Gene Therapy from the Clinic to Commercialization Scaling Up the AAV Production Process

As gene therapy is experiencing a second wave of interest, recombinant adeno-associated virus (rAAV) has rapidly emerged as one of the most attractive viral transfer tools, thanks to its favorable safety profile and long-term transgene expression. The recent approval of rAAV molecules for the treatment of congenital amaurosis and spinal muscular atrophy has been paving the road for the development of several rAAV-based therapeutics targeting a continuously increasing range of indications.

Rapid Development and Scale-Up of Biosimilars: A Case Study of Cell Line and Process Development

Increasing availability of genomic and transcriptomic resources for industrially important cell lines coupled with advances in genome editing technology have opened new avenues for cell line development. These developments are poised to help biosimilar manufacturing, which requires targeting pre-defined product quality attributes, e.g., glycoform, to match the innovator's range.

High-Performance CHO-Stabilized Cell Lines for Biopharmaceutical Development

Biological therapeutics and diagnostics (theranostics) are rapidly growing products in the pharmaceutical market. They include various monoclonal antibodies (mAbs), vaccines, hormones, and other proteins, all of which have wide range of applications. Biotherapeutic proteins represent a mainstay of treatment for a multitude of conditions, for example, autoimmune disorders, hematologic disorders, hormonal dysregulation, cancers, infectious diseases and genetic disorders.

* For research use only. Not intended for any clinical use.

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