Research Resource

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Research Areas

Protein Lactylation: A New Link between Metabolism and Gene Expression Regulation

In the long journey of life sciences research, scientists have continuously unveiled the mysteries of life activities. Recently, the discovery of a novel post-translational modification (PTM)—protein lactylation—has provided a new perspective on the connection between cellular metabolism and gene expression regulation.

Inflammasomes: The Alarm System of the Innate Immune System

In our bodies, there exists a complex and intricate defense system that constantly shields us from various threats.

Tumor Macrophage Guide: Functions, Roles, and Research Perspectives

Tumor-associated macrophages (TAMs) are macrophages that either infiltrate tumor tissues or reside in the tumor microenvironment (TME).

Regulatory Mechanisms of Ferroptosis and Nine Major Research Directions

In recent years, ferroptosis, a novel form of cell death, has attracted widespread attention. Unlike traditional forms of cell death such as apoptosis and necrosis...

Next-Generation Targeted Therapy Strategies: Design Optimization for ADCs and PDCs

Targeted therapy has shown significant potential in cancer treatment by directly targeting specific molecular markers on tumor cells, significantly improving treatment selectivity and efficacy.

Mitophagy: Essential Mechanisms for Cellular Health and Disease Prevention

Mitochondria, as crucial semi-autonomous organelles within cells, are primarily responsible for energy production.

Immune Checkpoints: A New Hope in Cancer Treatment

Cancer remains one of the deadliest diseases worldwide. According to the latest data from the National Cancer Center, China saw approximately 4.064 million new cancer cases and 2.4135 million deaths in 2016.

TL1A as A Popular Therapeutic Target for Inflammatory Bowel Disease

TL1A, also called TNFSF15, is a member of tumor necrosis factor family. It is expressed in different immune cell, such as monocyte, macrophage, dendritic cell, T cell and non-immune cell, for example, synovial fibroblast, endothelial cell. TL1A competitively binds to death receptor 3 or decoy receptor 3, providing stimulatory signal for downstream signaling pathways, and then regulates proliferation, activation, apoptosis of and cytokine, chemokine production in effector cells.

Novel Prime Editor Enables Low Off-Target, Small Size, Efficient Gene Editing

Prime editing (PE), also known as pilot editing, as a new type of gene editing tool, is capable of generating precise substitutions, deletions, or insertions of DNA without producing DNA double-strand breaks, and has been widely used in fields such as basic research, agricultural breeding, and gene therapy, and is expected to enter human clinical trials.

Knockout Cell Lines in The Development of Novel Disease Therapies

Knockout cell refers to the use of CRISPR technology for gene editing, through the design of specific sgRNA targeting the cut site of the target gene, so that the Cas9 protein binds to the sgRNA and "cut" the target gene from the cell.

* For research use only. Not intended for any clinical use.

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