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TRPV1, the founding member of the 'vanilloid' TRP subfamily, is formerly known as the vanilloid receptor VR1. Vanilloid, because of its archetypal activators, capsaicin and resiniferatoxin, shares a vanillyl moiety essential for bioactivity.
Safe and effective treatment of atrial fibrillation (AF) remains a major unmet medical need in our society, and the problem is growing as the prevalence of AF continues to increase with the aging of the baby boom generation.
Functional and pathophysiological studies have led to better understanding of the clinical spectrum, ion channel structures and cellular electrophysiology involving dynamics of intracellular calcium cycling in many subtypes of these disorders.
The liver X receptors (LXRs) are pivotal regulators of lipid homeostasis in mammals. These transcription factors control the expression of a battery of genes involved in the uptake, transport, efflux and excretion of cholesterol in a tissue-dependent manner.
Terrestrial plants can convert atmospheric CO2 into diverse and abundant aromatic compounds, thus providing high-value chemicals and considerable promise for carbon storage.
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