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Immune checkpoint blockade inhibitors (CBIs) targeting cytotoxic T lymphocyte associated protein-4 (CTLA-4) and program death receptor-1 (PD-1) or its ligand-1 (PD-L1) have transformed the outlook of many patients with cancer.
Prime editing (PE), also known as pilot editing, as a new type of gene editing tool, is capable of generating precise substitutions, deletions, or insertions of DNA without producing DNA double-strand breaks, and has been widely used in fields such as basic research, agricultural breeding, and gene therapy, and is expected to enter human clinical trials.
TL1A, also called TNFSF15, is a member of tumor necrosis factor family. It is expressed in different immune cell, such as monocyte, macrophage, dendritic cell, T cell and non-immune cell, for example, synovial fibroblast, endothelial cell. TL1A competitively binds to death receptor 3 or decoy receptor 3, providing stimulatory signal for downstream signaling pathways, and then regulates proliferation, activation, apoptosis of and cytokine, chemokine production in effector cells.
Cancer remains one of the deadliest diseases worldwide. According to the latest data from the National Cancer Center, China saw approximately 4.064 million new cancer cases and 2.4135 million deaths in 2016.
In recent years, ferroptosis, a novel form of cell death, has attracted widespread attention. Unlike traditional forms of cell death such as apoptosis and necrosis...
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