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CACNA1C is one of the most universally reproduced risk genes for neuropsychiatric disorders including bipolar disorder, schizophrenia, and major depressive disorder.
Human immunodeficiency virus (HIV), the causative agent of acquired immunodeficiency syndrome (AIDS), has become one of the most costly and deadly epidemics in human history. Once thought of as a death sentence, HIV infection has become a chronically manageable disease.
Graves' orbitopathy (GO) is an inflammatory autoimmune disorder of the orbit. The immune basis of the disease is suggested by a perivascular and diffuse infiltration of CD4+ and CD8+ T cells, B cells, plasma cells and macrophages.
The main role of the immune system is to protect the organism against damage by ensuring an adequate response against various pathogens such as viruses, fungi, bacteria, parasites, environmental harm stimuli including allergens, haptens, and also from damage that may result from inappropriate immune system activation.
Cancer immunotherapy can reverse tumor immune escape by suppressing immune checkpoint pathways. It is possible that the inhibition of pathway checkpoints, including CTLA4, PD1 and PDL1, could activate T cells to attack and eliminate cancer.
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