Genes

Role of G Protein-coupled Receptor (GPCR) in Neuropsychiatric Disorders: Focusing on Depression

Mood disorders and in particular major depression, remain one of the most prevalent psychiatric disorders with a lifetime prevalence rate over 16% and affects twice as many women as men.

Research of The Role of PD-1/PD-L1 Pathway in Cancer

Tumor cells can escape the immune surveillance and disrupt immune checkpoint of host in several methods, therefore, to avoid the elimination from the host immune system. Numerous pathways are utilized by cancers to up-regulate the negative signals through cell surface molecules.

Research of Liver X Receptors in Cardiovascular Disease

The liver X receptors (LXRs) are pivotal regulators of lipid homeostasis in mammals. These transcription factors control the expression of a battery of genes involved in the uptake, transport, efflux and excretion of cholesterol in a tissue-dependent manner.

LAG-3 in Cancer Immunotherapy

Cancer immunotherapy can reverse tumor immune escape by suppressing immune checkpoint pathways. It is possible that the inhibition of pathway checkpoints, including CTLA4, PD1 and PDL1, could activate T cells to attack and eliminate cancer.

Research of KCNH2 Mutations in Arrhythmias

Functional and pathophysiological studies have led to better understanding of the clinical spectrum, ion channel structures and cellular electrophysiology involving dynamics of intracellular calcium cycling in many subtypes of these disorders.

Research of Thyrotropin/IGF-1 Receptor in Graves' Ophthalmopathy

Graves' orbitopathy (GO) is an inflammatory autoimmune disorder of the orbit. The immune basis of the disease is suggested by a perivascular and diffuse infiltration of CD4+ and CD8+ T cells, B cells, plasma cells and macrophages.

Research of HAVCR2 in Cancer Immunotherapy

Cancer immunotherapy is a type of cancer treatment using the body's own immune system to fight against cancer. Dr. William Coley is reported to be the first one pioneered the treatment of cancer with immunotherapy.

Research of Glucagon-Like Peptide 1(GLP-1) in The Treatment of Type 2 Diabetes(T2D)

Type 2 diabetes (T2D), the major type of diabetes mellitus (DM), is a long term metabolic disorder primarily occurs as a result of obesity and not enough exercise.[1] T2D is characterized by high blood sugar, insulin resistance, and relative lack of insulin.

Current Research and Role of A2A Receptors in Parkinson's Disease

The adenosine receptors (ARs) in the nervous system act as a kind of "go-between" to regulate the release of neurotransmitters and the action of neuromodulators. Receptor-receptor interactions and AR-transporter interplay occur as part of the adenosine's attempt to control synaptic transmission[1].

CTLA-4 and PD-1 Blockade in Cancer Immunotherapy

The potential of T cells to attack and destroy tumors has long been recognized. Recent experimental evidence has also demonstrated that T cell surveillance throughout the life of an organism functions to prevent tumor development.

* For research use only. Not intended for any clinical use.

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