Genes

Emerging Role of CLDN6 in Cancer

Claudins (CLDNs) are the most important tight junction proteins, which are mainly expressed in endothelial cells or epithelial cells in a tissue-specific manner.

CD47 as A Potential Target for Infectious Disease and Cancer Therapy

CD47 is a widely expressed cellular receptor well known for its immunoregulatory functions.

Tools for sgRNA Target Finding and Evaluation, and Prediction of Off-Target Effects

Creative Biogene introduces customers to several tools for sgRNA target discovery and evaluation and for predicting off-target effects.

Developed Strategies to Minimize the Off-Target Effects in CRISPR-Cas-Mediated Genome Editing

Clustered regularly interspaced short palindromic repeats (CRISPR)/Cas9 emerged as a substantial tool due to its simplicity in use, less cost and extraordinary efficiency than the conventional gene-editing tools...

TMEFF2: A New Target for Multiple Cancers

Transmembrane protein with an EGF-like and two Follistatin-like domains 2 (TMEFF2) is a 374-residue long type-I transmembrane proteoglycan which is proteolytically shed from the cell surface.

HER2 As an Ideal Target for Antibody Drugs

The long-sought discovery of HER2 as an actionable and highly sensitive therapeutic target was a major breakthrough for the treatment of highly aggressive HER2-positive breast cancer, leading to approval of the first HER2-targeted drug-the monoclonal antibody trastuzumab-almost 25 years ago.

Research of The Molecular Mechanism of NARF in Promoting Breast Cancer Metastasis

Breast cancer is the leading cause of cancer death for women globally, and the vast majority of breast cancer–related deaths are due to metastasis. Advanced breast cancers are characterized by intratumoral hypoxia, which is associated with metastasis, treatment failure, and patient mortality.

Research of Biological Functions and Potential Molecular Mechanisms of TTC9 Gene in Lung Adenocarcinoma

Lung adenocarcinoma (LUAD) is one of the most commonly diagnosed subtypes of lung cancer, and one of the deadliest cancers. Tetratricopeptide repeat domain 9A (TTC9) is upregulated and has played an oncogenic role in some malignant tumors. However, the expression and role of TTC9 has not yet been elucidated in LUAD.

Research of The Role of CLN7 in The Regulation of Lysosomal Function

Lysosomes play a vital role in eliminating worn-out proteins, damaged organelles, and other unnecessary materials in eukaryotic cells. Dysfunction of lysosomes often leads to lysosomal storage diseases (LSDs), which are characterized by abnormal accumulation of unmetabolized substrates within lysosomes.

Research on The Regulatory Mechanism of Manganate Pathway to Enhance Plant Carbon Dioxide Conversion

Terrestrial plants can convert atmospheric CO₂ into diverse and abundant aromatic compounds, thus providing high-value chemicals and considerable promise for carbon storage.

* For research use only. Not intended for any clinical use.

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