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Acute myeloid leukemia (AML), a malignant clonal disorder of the hematopoietic system, is characterized by an enormous heterogeneity of acquired genetic and epigenetic changes in hematopoietic precursor cells and by impaired mechanisms of proliferation, differentiation, and self-renewal.
Type 2 diabetes (T2D), the major type of diabetes mellitus (DM), is a long term metabolic disorder primarily occurs as a result of obesity and not enough exercise.[1] T2D is characterized by high blood sugar, insulin resistance, and relative lack of insulin.
Diabetes is a disease that seriously threatens human health, and type 2 diabetes makes up about 90% of cases of diabetes[1]. Type 2 diabetes is a long-term metabolic disorder that is characterized by high blood sugar, insulin resistance, and relative lack of insulin.
The adenosine receptors (ARs) in the nervous system act as a kind of "go-between" to regulate the release of neurotransmitters and the action of neuromodulators. Receptor-receptor interactions and AR-transporter interplay occur as part of the adenosine's attempt to control synaptic transmission[1].
Mood disorders and in particular major depression, remain one of the most prevalent psychiatric disorders with a lifetime prevalence rate over 16% and affects twice as many women as men.
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