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As gene therapy is experiencing a second wave of interest, recombinant adeno-associated virus (rAAV) has rapidly emerged as one of the most attractive viral transfer tools, thanks to its favorable safety profile and long-term transgene expression. The recent approval of rAAV molecules for the treatment of congenital amaurosis and spinal muscular atrophy has been paving the road for the development of several rAAV-based therapeutics targeting a continuously increasing range of indications.
Knock-in (KI) cell lines are crucial tools in biomedical research, predominantly used to model diseases, perform gene function analyses, and develop therapeutic strategies. Their construction involves integrating a specific allele or genetic alteration into a particular locus on the cell's chromosome.
The field of bioscience research has been revolutionized by the emergence of CRISPR-Cas9 technology. This groundbreaking tool allows scientists to edit genes with unprecedented precision and efficiency, enabling them to unravel the mysteries of cellular processes and diseases.
Creative Biogene provides an overview on recent advances in CHO cell line development, targeted genome manipulation techniques, selection systems and screening methods currently used in recombinant protein production.
Creative Biogene explores the diverse applications of p53 knockout cell lines, shedding light on their significance and impact in cancer research and beyond.
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