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Cas9, a CRISPR-associated endonuclease, has revolutionized the field of genome editing by enabling precise and efficient modifications to the DNA sequence.
While it is true that some tumors or diseases are due to alterations in the genetic information of the genome itself, epigenetic regulation can sometimes better elucidate the mechanisms of tumor or disease development.
Knockout cell refers to the use of CRISPR technology for gene editing, through the design of specific sgRNA targeting the cut site of the target gene, so that the Cas9 protein binds to the sgRNA and "cut" the target gene from the cell.
Mitochondria, as crucial semi-autonomous organelles within cells, are primarily responsible for energy production.
Tumor-associated macrophages (TAMs) are macrophages that either infiltrate tumor tissues or reside in the tumor microenvironment (TME).
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