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Liver fibrosis is a wound-healing response that results from various chronic damages. If the causes of damage are not removed or effective treatments are not given in a timely manner, it will progress to cirrhosis, even liver cancer. Currently, there are no specific medical therapies for liver fibrosis.
HIV-1 derived lentiviral vector is an efficient transporter for delivering desired genetic materials into the targeted cells among many viral vectors. Genetic material transduced by lentiviral vector is integrated into the cell genome to introduce new functions, repair defective cell metabolism, and stimulate certain cell functions.
To fully exploit the gene editing potential of CRISPR/Cas9, they must be efficiently introduced into target cells or tissues using appropriate vectors. Recombinant viral vectors have been developed using ability of viruses to transfer foreign genetic material into cells to deliver therapeutic genes to diseased tissues.
There has been a long-lasting interest in using viral vectors, especially adenoviral vectors, to deliver therapeutic genes for the past two decades. Among all currently available viral vectors, adenovirus is the most efficient gene delivery system in a broad range of cell and tissue types.
Creative Biogene introduces customers to the basic functions of self-replicating RNA viral vectors and describes various pre-clinical and clinical applications.
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