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The successful execution of neurobiology studies requires methods that are highly targetable, efficient, and precise. The arsenal of new sensors, actuators, recombinases, genes, RNA and base editing enzymes, and other genetically encoded tools for studying the nervous system is rapidly growing.
Adeno-associated viral vectors (AAVs) are increasingly useful preclinical tools in neuroscience research studies for interrogating cellular and neurocircuit functions and mapping brain connectivity. Clinically, AAVs have for transformative research and therapeutics in the neurosciences.
Chimeric antigen receptor (CAR) T-cells represent a paradigm shift in cancer immunotherapy and a new milestone in the history of oncology. Among them, CD19-targeted drugs have achieved unprecedented success in the treatment of B-cell malignancies and were approved by the US FDA in 2017.
Exosomes have many biological functions as short- and long distance nanocarriers for cell-to-cell communication. They allow the exchange of complex information between cells, and thereby modulate various processes such as homeostasis, immune response and angiogenesis, in both physiological and pathological conditions.
Genetic engineering has revolutionized various fields, from agriculture to medicine. One powerful tool in this domain is Cre recombinase, a naturally occurring enzyme that allows precise manipulation of genetic material.
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