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Cat.No. : CSC-RR0548 Host Cell: Molm13
| Cat. No. | CSC-RR0548 |
| Description | This cell line is engineered to stably overexpress luciferase reporter gene in Molm13. |
| Gene | Luciferase |
| Host Cell | Molm13 |
| Host Cell Species | Homo sapiens (Human) |
| Stability | Validated for at least 10 passages |
| Application | 1. Gene expression studies 2. Protein localization 3. Drug screening and toxicology 4. Live cell imaging |
| Quality Control | Negative for bacteria, yeast, fungi and mycoplasma. |
| Shipping | Dry ice |
| Storage | Liquid nitrogen |
| Revival | Rapidly thaw cells in a 37°C water bath. Transfer contents into a tube containing pre-warmed media. Centrifuge cells and seed into a 25 cm2 flask containing pre-warmed media. |
| Mycoplasma | Negative |
| Format | One frozen vial containing millions of cells |
| Storage | Liquid nitrogen |
| Safety Considerations |
The following safety precautions should be observed. 1. Use pipette aids to prevent ingestion and keep aerosols down to a minimum. 2. No eating, drinking or smoking while handling the stable line. 3. Wash hands after handling the stable line and before leaving the lab. 4. Decontaminate work surface with disinfectant or 70% ethanol before and after working with stable cells. 5. All waste should be considered hazardous. 6. Dispose of all liquid waste after each experiment and treat with bleach. |
| Ship | Dry ice |
The researchers investigated how maternally expressed gene 3 (MEG3) combats chemoresistance in acute myeloid leukemia (AML). They discovered that MEG3 and microRNA (miR)-493-5p are downregulated in resistant AML cells when compared to parental cells. MEG3 increases miR-493-5p levels, which target methyltransferase-like 3 (METTL3). METTL3, in turn, stimulates MYC expression by increasing its m6A alteration. MEG3 and miR-493-5p overexpression, as well as METTL3 deletion, decreased cell growth and increased apoptosis in HL-60 and Molm13 cell lines, respectively. MEG3 also boosted AML cells' sensitivity to arabinocytosine (AraC). Suppressing miR-493-5p reversed the effects of MEG3. These data indicate that MEG3 increases AML cell chemosensitivity by modulating the miR-493-5p/METTL3/MYC axis.
Figure 1. The researchers confirmed that METTL3 is a miR-493-5p target by doing dual luciferase reporter tests with the MOLM13 cell line. They measured METTL3 expression in distinct AML and normal samples and discovered substantial differences. (Wang A, et al., 2022)
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As a user of the Luciferase Reporter Cell Line - Molm13, I highly rate its performance and practicality. Using the Luciferase Reporter Cell Line - Molm13 has enabled me to monitor cell biology processes in real-time and dynamically in my research, which has greatly enhanced my control and reproducibility of experimental results.
French
02/19/2023
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