Luciferase Reporter Cell Line - A20

A20 cells are a cell line originally derived from B-cell lymphoma in aged BALB/c mice. A20 cells are suitable for in vitro and in vivo experiments. These cells will form tumors and spontaneous metastases in immunocompromised and syngeneic Balb/c mice. Depending on the route of vaccination, implanted A20 cells can transfer to many sites, including bone marrow, liver, spleen, lymph nodes, ovaries, and peritoneal cavity. A20 cells are used in medical research such as drug screening or vaccine target selection. A20 cells are also highly sensitive to immunomodulatory antibodies and are therefore often used in immunotherapeutic drug research. Luciferase Reporter Cell Line - A20 is a genetically engineered cell line designed to express luciferase, a bioluminescent enzyme, under specific biological conditions. The luciferase gene in this reporter cell line acts as a reporter gene, meaning it produces a measurable phenotype when a specific biological process is activated or inactivated. Because luciferase produces light when it is enzymatically active, luciferase expression levels in the A20 cell line can be easily measured using bioluminescence imaging or a photometer.