Luciferase Reporter Cell Line - AGS

The AGS-Luciferase Reporter Cell Line (AGS-Luc) is a stable reporter cell model generated by integrating a luciferase reporter gene into the AGS human gastric adenocarcinoma cell line to achieve constitutive expression. AGS cells are a widely used epithelioid gastric cancer cell line derived from human gastric adenocarcinoma; they are frequently employed in research areas such as gastric tumor biology, host-pathogen interactions, epithelial cell signaling, drug responses, and the mechanisms of cancer progression. Because AGS cells retain key characteristics of gastric epithelial tumor cells, they provide a practical in vitro platform for studying pathways associated with gastric cancer. In the AGS-Luc reporter cell line, the luciferase gene is stably integrated into the AGS genome, enabling the cells to constitutively express luciferase.

This cell product is suitable for a wide range of applications in gastric cancer research and reporter-based biological assays. A primary application is the assessment of cell viability, proliferation, and cytotoxicity; in these experiments, changes in the luminescent signal allow for the rapid, quantitative monitoring of cell growth or the inhibitory effects of anti-cancer compounds. The AGS-Luc reporter cell line is also well-suited for drug screening programs, including the evaluation of small-molecule drugs, natural products, targeted therapies, chemotherapeutic agents, and combination treatment strategies against gastric cancer. Given the high sensitivity of luciferase assays and their compatibility with multi-well plate formats, this cell line supports medium- to high-throughput screening workflows. Another significant application lies in tumor xenograft studies: following the implantation of AGS-Luc cells into immunodeficient mice, tumor growth and metastasis can be monitored non-invasively using bioluminescence imaging technology.