Luciferase Reporter Cell Line - TE-10

With great fatality rates, esophageal cancer is among the most common malignancies worldwide. Long non-coding RNAs (lncRNAs), especially GIHCG, have been shown in recent research to be quite important in tumor development. GIHCG is increased in esophageal cancer tissues and cell lines, researchers have shown, which promotes cancer cell proliferation, invasion, and migration while suppressing death. In particular, GIHCG acts as a sponge for miR-29b-3p, which causes the target gene ANO1 to be upregulated—a crucial role in esophageal cancer pathogenies. This intricate interaction was confirmed through luciferase reporter assays, which measured the regulatory dynamics between these molecular players in relevant cell lines like TE-10.

Figure 1. The researchers utilized luciferase reporter assays and qRT-PCR to evaluate the interaction between miR-29b-3p and ANO1 in TE-10 cells. (Zhao W, et al., 2020)

Creative Biogene's Luciferase Reporter Cell Line - TE-10 can facilitate similar investigations into gene regulation mechanisms in esophageal cancer and other malignancies. Utilizing our TE-10 cell line can enhance studies aimed at unraveling the complexities of tumor biology, thereby supporting the development of innovative cancer therapies.