Luciferase Reporter Cell Line - SNU-5

SNU-5 is a human gastric cancer cell line established from a patient with poorly differentiated adenocarcinoma of the stomach. The SNU5 cell line was isolated by J. Park in 1987 from metastatic ascites of a 33-year-old Asian female patient with gastric cancer. Since then, SNU5 cells have been used as a model of colon cancer in many studies. The SNU-5 cell line has demonstrated sensitivity to drugs targeting the MET receptor tyrosine kinase (RTK) pathway. Targeting the MET pathway with specific inhibitors disrupts aberrant signaling and shows potential for treating gastric cancer. The sensitivity of SNU-5 cells to MET-targeted drugs provides a valuable model for studying the effects of inhibiting this pathway and evaluating potential therapeutic strategies for gastric cancer patients.

GFP reporter cell lines, especially SNU-5, are key tools in the fields of molecular biology and cancer research. GFP is a protein that emits bright green fluorescence under light ranging from blue to ultraviolet light and is an excellent marker for monitoring cellular and molecular events. In SNU-5 cells, GFP can be used to visualize and quantify various biological processes, such as gene expression, protein-protein interactions, cell proliferation, and apoptosis. The stability and long-term expression of GFP in these cells ensures data reliability and consistency, which is essential for longitudinal studies.