Luc Reporter Cell Line-A549

A549 cells are adenocarcinoma human alveolar basal epithelial cells, a cell line first developed by D. J. Giard et al. in 1972. Cancerous lung tissue was removed and cultured from a transplanted tumor in a 58-year-old white man. A549 cells are found in the lung tissue from which they originate, are squamous, and are responsible for the diffusion of certain substances, such as water and electrolytes, into the alveoli. These cells are capable of synthesizing lecithin and contain high levels of unsaturated fatty acids, which are important for maintaining membrane phospholipids. A549 cells are used as a model for lung cancer research and to develop drug therapies for lung cancer. Luc Reporter Cell Line-A549 is a transgenic human lung cancer cell line that stably expresses the luciferase gene, making it a valuable tool in a variety of scientific research settings. Luciferase is an enzyme that produces light when it oxidizes a substrate. There are different types of luciferase, such as firefly luciferase and Renilla luciferase, each with its own unique characteristics such as emission wavelength and reaction speed. Luciferase has many applications in scientific research, including gene expression assays, bioluminescence imaging, and bacterial detection. This specific cell line type is designed for convenient high-throughput screening of therapeutic agents as well as in vivo monitoring of tumor growth in xenograft models.