GFP Reporter Cell Line - MV4-11

MV-4-11 cells are macrophages isolated from blasts from a 10-year-old male with biphenotypic B myelomonocytic leukemia. The MV-4-11 cell line is an important resource in the study of acute leukemias, especially acute myeloid leukemia (AML). MV4-11 cells are characterized by a high proliferation rate and the presence of certain genetic abnormalities. A translocation between chromosomes 4 and 11 results in the generation of the MLL-AF4 fusion gene, which plays a crucial role in leukemogenesis and contributes to the aggressiveness of leukemias. The presence of the MLL-AF4 fusion gene makes these cells particularly important for the study of understanding the molecular mechanisms of leukemogenesis and of targeted therapies aimed at disrupting the function of this oncogenic fusion protein. The GFP reporter cell line – MV4-11 is an excellent scientific tool for studying a variety of biological processes. This cell line was engineered to stably express a green fluorescent protein (GFP) reporter gene in MV4-11 cells. GFP is a protein that emits bright green fluorescence when expressed. This unique light signal allows scientists to track and visualize cells in real time under normal physiological conditions. When integrated into the MV4-11 cell line, the GFP reporter provides an efficient and reliable method to track gene expression and cellular processes. Using fluorescence microscopy, researchers can monitor the status of cells, perform gene expression studies, and evaluate the effects of drugs or other experimental manipulations.