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Cat.No. : CSC-RR0553 Host Cell: MM1.R
| Cat. No. | CSC-RR0553 |
| Description | This cell line is engineered to stably express GFP reporter gene in MM1.R. |
| Gene | GFP |
| Host Cell | MM1.R |
| Host Cell Species | Homo sapiens (Human) |
| Stability | Validated for at least 10 passages |
| Reporter Type | Fluorescent protein |
| Application | 1. Gene expression studies 2. Protein localization 3. Drug screening and toxicology 4. Live cell imaging |
| Quality Control | Negative for bacteria, yeast, fungi and mycoplasma. |
| Shipping | Dry ice |
| Storage | Liquid nitrogen |
| Revival | Rapidly thaw cells in a 37°C water bath. Transfer contents into a tube containing pre-warmed media. Centrifuge cells and seed into a 25 cm2 flask containing pre-warmed media. |
| Mycoplasma | Negative |
| Format | One frozen vial containing millions of cells |
| Storage | Liquid nitrogen |
| Safety Considerations |
The following safety precautions should be observed. 1. Use pipette aids to prevent ingestion and keep aerosols down to a minimum. 2. No eating, drinking or smoking while handling the stable line. 3. Wash hands after handling the stable line and before leaving the lab. 4. Decontaminate work surface with disinfectant or 70% ethanol before and after working with stable cells. 5. All waste should be considered hazardous. 6. Dispose of all liquid waste after each experiment and treat with bleach. |
| Ship | Dry ice |
A: Researchers can co-culture GFP-labeled MM1.R cells with bone marrow stromal cells or within a bone marrow mimicking matrix to observe interactions and effects on cell proliferation, survival, and drug resistance. The GFP fluorescence facilitates tracking and quantification of myeloma cells under various microenvironmental conditions.
A: The GFP-labeled MM1.R cells allow for real-time tracking of myeloma cells in vitro and in vivo, enabling researchers to directly observe the targeting and eradication of these cells by CAR-T therapy. This cell line allows for the quantification of CAR-T cell-mediated cytotoxicity and the assessment of therapeutic efficacy over time.
A: Yes, the cell line can be exposed to various anti-myeloma drugs to develop resistant cell populations. GFP fluorescence can then be used to isolate surviving cells for further analysis, such as gene expression profiling and signaling pathway studies, to elucidate the mechanisms underlying drug resistance.
A: Gene editing tools, like CRISPR/Cas9, can be applied to GFP-labeled MM1.R cells to knock out or overexpress target genes. The modified cells can then be analyzed using migration and invasion assays, with GFP fluorescence enabling easy visualization and quantification of cell movements.
A: The GFP fluorescence in MM1.R cells provides a means to test the sensitivity and specificity of novel imaging agents in recognizing and binding to myeloma cells. In vivo imaging of mouse models inoculated with GFP-labeled MM1.R cells can demonstrate the agents' ability to detect small numbers of myeloma cells in various tissues.
If your question is not addressed through these resources, you can fill out the online form below and we will answer your question as soon as possible.
We can monitor gene expression in real-time, providing a dynamic view of cellular processes without the need for time-consuming endpoint assays.
United Kingdom
11/21/2022
The fluorescence intensity can be measured quantitatively, offering a straightforward method to assess changes in gene expression levels.
Germany
06/14/2020
The use of GFP negates the need for invasive procedures or cell lysis, allowing for the study of living cells over extended periods.
Germany
08/16/2022
The GFP Reporter Cell Line - MM1.R allows for direct visualization of gene expression through the green fluorescence protein, simplifying and speeding up analysis.
French
09/29/2022
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