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Sodium channels are integral membrane proteins that form a Na+ permeable pore through the plasma membrane and allow ion flux. There are two major classes of sodium channels in mammals: the voltage-gated sodium channel (also called "VGSC" or "Nav channel") family and the epithelial sodium channel (also called "ESC" or "ENaC") family. NaV is present in the membranes of most excitable cells and exists as heterodimers or heterotrimers of 1 α- and 1 or 2 β-subunits. NaV channels are responsible for the initiation and propagation of action potentials in excitable cells, including nerve, muscle, and neuroendocrine cell types. ENaC is found in absorptive epithelial cells such as the distal renal tubules, alveolar epithelium, and distal colon and is responsible for sodium reabsorption. They exist as heterotetramers of α-, β- and γ-subunits, the main one being 2α:1β:1γ.
A surprising number of genetic disorders are caused by mutations in sodium channels, including inherited forms of periodic paralysis, cardiac arrhythmias, epilepsy, migraines, peripheral neuropathy, and chronic pain. In most cases, these are genetically dominant diseases in which mutations cause gain-of-function effects at the molecular and cellular levels, and the resulting hyperexcitability contributes to the symptoms of the disease. Currently, sodium channels are blocked by drugs used clinically as local anesthetics, antiarrhythmics, and antiepileptics. Sodium channel-blocking drugs are also in development to treat chronic pain. The local anesthetic binds to specific receptors within the pore of the sodium channel, which is formed by the S6 fragment in domains I, III, and IV. Their combination blocks the movement of ions through the pore and stabilizes the inactive state of the sodium channel.
Transfected stable cell lines are important research tools for drug discovery, compound screening, and gene therapy research. Based on many years of experience in cell line development, Creative Biogene has accessioned a large collection of cell lines that stably express high levels of sodium channels. These sodium channel stable cell lines have excellent in vitro assay sensitivity and reproducibility. They enable the assessment of ion channel function by detecting electrophysiological signals.
Please browse our sodium channel stable cell lines collection to find your desired one.
| Cat.No. | Product Name | Price |
|---|---|---|
| CSC-RI0047 | Human SCN1A Stable Cell Line-HEK293 | Inquiry |
| CSC-RI0048 | Human SCN2A Stable Cell Line-CHO-K1 | Inquiry |
| CSC-RI0049 | Human SCN3A Stable Cell Line-CHO-K1 | Inquiry |
| CSC-RI0050 | Human SCN4A Stable Cell Line-HEK293 | Inquiry |
| CSC-RI0051 | Human SCN5A Stable Cell Line-HEK293 | Inquiry |
| CSC-RI0052 | Human SCN8A Stable Cell Line-HEK293 | Inquiry |
| CSC-RI0053 | Human SCN9A Stable Cell Line-HEK293 | Inquiry |
| CSC-RI0054 | Human SCN10A Stable Cell Line-HEK293 | Inquiry |
| CSC-RI0086 | Human SCNN1A/SCNN1B/SCNN1G Stable Cell Line-CHO-K1 | Inquiry |
| CSC-RI0154 | Human SCN1A Stable Cell Line-CHO | Inquiry |
| CSC-RI0157 | Human SCN2A Stable Cell Line-HEK293 | Inquiry |
| CSC-RI0159 | Human SCN3A Stable Cell Line-HEK293 | Inquiry |
| CSC-RI0162 | Human SCN4A Stable Cell Line-CHO-K1 | Inquiry |
| CSC-RI0164 | Human SCN5A Stable Cell Line-CHO-K1 | Inquiry |
| CSC-RI0168 | Human SCN8A Stable Cell Line-CHO | Inquiry |
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