Human SCN4A Stable Cell Line-CHO-K1

Name: Human SCN4A Stable Cell Line-CHO-K1
SKU: CSC-RI0162
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : CSC-RI0162

Host Cell : CHO-K1 Size : >1x10⁶ frozen cells/vial

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Cell Line Information

Cell Culture Information

Safety and Packaging

Gene Information

Cat. No.	CSC-RI0162
Description	This cell line is engineered to overexpress human SCN4A.
Background	The human SCN4A gene encodes the pore-forming subunit of Nav1.1, a voltage-gated sodium channel expressed in skeletal muscle. SCN4A mutations cause paramyotonia congenita and hypokalemic periodic paralysis. Nav1.4 are therapeutic targets in myotonia.
Target Gene	SCN4A
Gene Species	Homo sapiens (Human)
Abbr	CHO-HuSCN4A
Alias	SCN4A, HOKPP2, HYKPP, HYPP, NAC1A, Na(V)1.4, Nav1.4, SkM1
Host Cell	CHO-K1
Host Cell Species	Cricetulus griseus (Chinese hamster)
Applications	1. Gene expression studies 2. Signaling pathway research 3. Drug screening and toxicology 4. Channelopathies research
Size	>1x10⁶ frozen cells/vial
Stability	Validated for at least 10 passages
Quality Control	Negative for bacteria, yeast, fungi and mycoplasma.
Storage	Liquid nitrogen
Shipping	Dry ice

Revival	Rapidly thaw cells in a 37°C water bath. Transfer contents into a tube containing pre-warmed media. Centrifuge cells and seed into a 25 cm2 flask containing pre-warmed media.
Growth Properties	Adherent
Morphology	Epithelial-like

Mycoplasma	Negative
Format	One frozen vial containing millions of cells
Storage	Liquid nitrogen
Safety Considerations	The following safety precautions should be observed. 1. Use pipette aids to prevent ingestion and keep aerosols down to a minimum. 2. No eating, drinking or smoking while handling the stable line. 3. Wash hands after handling the stable line and before leaving the lab. 4. Decontaminate work surface with disinfectant or 70% ethanol before and after working with stable cells. 5. All waste should be considered hazardous. 6. Dispose of all liquid waste after each experiment and treat with bleach.
Ship	Dry ice

Gene Name	SCN4A sodium channel, voltage-gated, type IV, alpha subunit [ Homo sapiens ]
Gene Symbol	SCN4A
Synonyms	HYPP; SkM1; HYKPP; NAC1A; HOKPP2; Nav1.4; Na(V)1.4
Gene Description	sodium channel, voltage-gated, type IV, alpha subunit
GeneID	6329
Uni ProtID	P35499
mRNA Refseq	NM_000334.4
Protein Refseq	NP_000325.4
Chromosome Location	17q23.3
Function	voltage-gated sodium channel activity;
Pathway	Axon guidance, organism-specific biosystem; Developmental Biology, organism-specific biosystem; Interaction between L1 and Ankyrins, organism-specific biosystem; L1CAM interactions, organism-specific biosystem;
MIM	603967

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