Our promise to you:
Guaranteed product quality, expert customer support.
24x7 CUSTOMER SERVICE
CONTACT US TO ORDER
Middle East respiratory syndrome coronavirus (MERS-CoV) is a life-threatening human virus that emerged in Saudi Arabia in the summer of 2012. MERS-CoV has a zoonotic origin, with camels serving as intermediate hosts that transmit the virus to humans. In general, MERS-CoV infection in healthy individuals results in subclinical or mild disease. In contrast, in patients with comorbidities, MERS-CoV infection often causes acute respiratory distress syndrome and multiorgan failure, leading to death. Understanding the pathogenesis of MERS-CoV requires knowledge of the viral genes involved in virulence as well as the host cell pathways modified by the infection.
MERS-CoV belongs to the subgenus Merbecovirus of the genus Betacoronavirus. The positive-sense single-stranded RNA genome of MERS-CoV is approximately 30 kb and contains 11 open reading frames (ORFs) in the order 5'-ORF1a, ORF1b, S, 3, 4a, 4b, 5, E, M, N, 8b -3', expressed by a nested set of eight mRNAs. Genus-specific genes 3, 4a, 4b and 5 are not essential for viral replication. MERS-CoV ORF clones have invaluable potential for virological research. They provide a controlled and safe approach to study the genetic makeup and mechanisms of MERS-CoV. Because the ORF clone mimics the exact gene sequence found in the virus, the researchers were able to decode the impact of each gene in the virus life cycle, from replication and immune evasion to infection capabilities.
Combining unique and versatile cloning technologies, Creative Biogene has created a large number of high-quality MERS-CoV ORF clones. Premade ORF clones eliminate the initial cloning and validation procedures for gene discovery studies. There is no need to perform tedious RNA isolation, cDNA synthesis, cloning, sequencing, and validation procedures steps. ORF clones allow scientists to more precisely map these interactions at the genetic level, revealing how the virus develops inside host cells and how it triggers an immune response. They could help researchers accelerate a better understanding of MERS-CoV and eventually conquer it.
Please browse our collection of MERS-CoV cDNA clones to find the one you want.
| Cat.No. | Product Name | Price |
|---|---|---|
| CDCB156820 | MERS-CoV CoV-E ORF clone (JX869059.2) | Inquiry |
| CDCB156821 | MERS-CoV CoV-orf5 ORF clone (JX869059.2) | Inquiry |
| CDCB156822 | MERS-CoV CoV-M ORF clone (JX869059.2) | Inquiry |
| CDCB156823 | MERS-CoV CoV-orf4b ORF clone (JX869059.2) | Inquiry |
| CDCB156824 | MERS-CoV CoV-orf4a ORF clone (JX869059.2) | Inquiry |
| CDCB156825 | MERS-CoV CoV-orf3 ORF clone (JX869059.2) | Inquiry |
| SCV2-PLA-44 | MERS-CoV S ORF clone | Inquiry |
| SCV2-PLA-45 | MERS-CoV ORF3 ORF clone | Inquiry |
| SCV2-PLA-46 | MERS-CoV E ORF clone | Inquiry |
| SCV2-PLA-47 | MERS-CoV ORF4a ORF clone | Inquiry |
| SCV2-PLA-48 | MERS-CoV ORF4b ORF clone | Inquiry |
| SCV2-PLA-49 | MERS-CoV M ORF clone | Inquiry |
| SCV2-PLA-50 | MERS-CoV ORF5 ORF clone | Inquiry |
| SCV2-PLA-51 | MERS-CoV N ORF clone | Inquiry |
| SCV2-PLA-52 | MERS-CoV ORF8b ORF clone | Inquiry |
Copyright © Creative Biogene. All rights reserved.