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Malaria remains a major health burden, killing approximately 405,000 people worldwide each year, approximately 67% of which occur in children under 5 years of age. Nearly all of these deaths were caused by the most virulent human parasite, Plasmodium falciparum. For many years, malaria research has focused on a small portion of the Plasmodium genome, leading to the identification of a few protective immune targets and fewer targets for new drug development.
An open reading frame (ORF) is a contiguous stretch of genetic sequence that has the potential to be translated to produce proteins—key elements of biological function. The identification and sequencing of these ORFs help to understand the genome structure of an organism and its characteristics and survival mechanisms. In P. falciparum, researchers have identified approximately 5,500 ORFs. These ORFs are challenging to study and manipulate due to their high A-T content (approximately 80-90%) and other unique genomic features. Thus, the development of a cloned P. falciparum ORF marks an important milestone in the study of malaria biology.
Creative Biogene, one of the leading biotechnology companies, offers a comprehensive selection of P. falciparum ORF clones. All clones are provided in vector form, allowing high-throughput, precise, and directed transfer of ORFs to a variety of vectors. With the help of P. falciparum ORF clones, scientists are now able to produce proteins under laboratory conditions that are nearly identical to those in the living parasite. By conducting such in vitro studies of the genetic material that P. falciparum replicates, researchers can greatly improve their understanding of how malaria survives, reproduces and causes disease in humans.
Creative Biogene can accelerate your research by providing sequence-verified P. falciparum ORFs. Please browse our P. falciparum ORF clones collection to find your desired one.
| Cat.No. | Product Name | Price |
|---|---|---|
| CDCB156351 | P. falciparum LDH ORF clone (XM_001349953.1) | Inquiry |
| CDCB156352 | P. falciparum MSP3 ORF clone (XM_001347593.1) | Inquiry |
| CDCB156353 | P. falciparum HPRT ORF clone (XM_001347370.1) | Inquiry |
| CDCB156354 | P. falciparum HRPII ORF clone (XM_002808697.1) | Inquiry |
| CDCB156355 | P. falciparum FAS2 ORF clone (AY966007.1) | Inquiry |
| CDCB156356 | P. falciparum AMA1 ORF clone (XM_001347979.1) | Inquiry |
| CDCB156357 | P. falciparum CSP ORF clone (XM_001351086.1) | Inquiry |
| CDCB156358 | P. falciparum MSP1 ORF clone (DQ414722.1) | Inquiry |
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